caa a22 4500 606212469 CHVBK 20210128101043.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10295-014-1538-9 doi (NATIONALLICENCE)springer-10.1007/s10295-014-1538-9 Recent advances in the metabolic engineering of Corynebacterium glutamicum for the production of lactate and succinate from renewable resources [Elektronische Daten] [Yota Tsuge, Tomohisa Hasunuma, Akihiko Kondo] Recent increasing attention to environmental issues and the shortage of oil resources have spurred political and industrial interest in the development of environmental friendly and cost-effective processes for the production of bio-based chemicals from renewable resources. Thus, microbial production of commercially important chemicals is viewed as a desirable way to replace current petrochemical production. Corynebacterium glutamicum, a Gram-positive soil bacterium, is one of the most important industrial microorganisms as a platform for the production of various amino acids. Recent research has explored the use of C. glutamicum as a potential cell factory for producing organic acids such as lactate and succinate, both of which are commercially important bulk chemicals. Here, we summarize current understanding in this field and recent metabolic engineering efforts to develop C. glutamicum strains that efficiently produce l- and d-lactate, and succinate from renewable resources. Society for Industrial Microbiology and Biotechnology, 2014 Corynebacterium glutamicum nationallicence Lactate nationallicence Succinate nationallicence Metabolic engineering nationallicence Tsuge Yota Organization of Advanced Science and Technology, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan aut Hasunuma Tomohisa Organization of Advanced Science and Technology, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan aut Kondo Akihiko Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan aut Journal of Industrial Microbiology & Biotechnology Springer Berlin Heidelberg 42/3(2015-03-01), 375-389 1367-5435 42:3<375 2015 42 10295 https://doi.org/10.1007/s10295-014-1538-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10295-014-1538-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsuge Yota Organization of Advanced Science and Technology, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan aut NATIONALLICENCE 700 1- Hasunuma Tomohisa Organization of Advanced Science and Technology, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan aut NATIONALLICENCE 700 1- Kondo Akihiko Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada, 657-8501, Kobe, Japan aut NATIONALLICENCE 773 0- Journal of Industrial Microbiology & Biotechnology Springer Berlin Heidelberg 42/3(2015-03-01), 375-389 1367-5435 42:3<375 2015 42 10295