caa a22 4500 606212485 CHVBK 20210128101043.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10295-014-1539-8 doi (NATIONALLICENCE)springer-10.1007/s10295-014-1539-8 Metabolic engineering of strains: from industrial-scale to lab-scale chemical production [Elektronische Daten] [Jie Sun, Hal Alper] A plethora of successful metabolic engineering case studies have been published over the past several decades. Here, we highlight a collection of microbially produced chemicals using a historical framework, starting with titers ranging from industrial scale (more than 50g/L), to medium-scale (5-50g/L), and lab-scale (0-5g/L). Although engineered Escherichia coli and Saccharomyces cerevisiae emerge as prominent hosts in the literature as a result of well-developed genetic engineering tools, several novel native-producing strains are gaining attention. This review catalogs the current progress of metabolic engineering towards production of compounds such as acids, alcohols, amino acids, natural organic compounds, and others. Society for Industrial Microbiology and Biotechnology, 2014 Sun Jie McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, 78712, Austin, TX, USA aut Alper Hal McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, 78712, Austin, TX, USA aut Journal of Industrial Microbiology & Biotechnology Springer Berlin Heidelberg 42/3(2015-03-01), 423-436 1367-5435 42:3<423 2015 42 10295 https://doi.org/10.1007/s10295-014-1539-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10295-014-1539-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sun Jie McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, 78712, Austin, TX, USA aut NATIONALLICENCE 700 1- Alper Hal McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, 78712, Austin, TX, USA aut NATIONALLICENCE 773 0- Journal of Industrial Microbiology & Biotechnology Springer Berlin Heidelberg 42/3(2015-03-01), 423-436 1367-5435 42:3<423 2015 42 10295