caa a22 4500 606213546 CHVBK 20210128101048.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00701-014-2274-7 doi (NATIONALLICENCE)springer-10.1007/s00701-014-2274-7 First description of pharmacoresistant epilepsy due to independent bilateral hypothalamic hamartomas [Elektronische Daten] [Anke Staack, Karl Strobl, Julia Scholly, Bernhard Steinhoff] Hypothalamic hamartomas (HHs) are rare developmental malformations consisting of mixed neurons and glial cells, usually unilaterally attached to the tuber cinereum or mammillary bodies. We report on two patients, both suffering from pharmacoresistant epilepsy, behavioural and cognitive disturbances. Ictal and interictal electroencephalographic (EEG) abnormalities appeared bilaterally and multiregionally with right-sided preponderance. Magnetic-resonance imaging (MRI) revealed independent bilateral hypothalamic hamartomas, more prominently on the right side. Endoscopic surgery of the right HH was performed in each patient, resulting in a significant seizure reduction in both cases. To the best of our knowledge, there are no other reports of independent bilateral HHs in the literature. Springer-Verlag Wien, 2014 Hypothalamic hamartoma nationallicence Bilateral nationallicence Endoscopic surgery nationallicence Epilepsy nationallicence Postoperative outcome nationallicence Staack Anke Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany aut Strobl Karl Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany aut Scholly Julia Medical and Surgical Epilepsy Units University of Strasbourg, Strasbourg, France aut Steinhoff Bernhard Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany aut Acta Neurochirurgica Springer Vienna 157/1(2015-01-01), 57-61 0001-6268 157:1<57 2015 157 701 https://doi.org/10.1007/s00701-014-2274-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-014-2274-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Staack Anke Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany aut NATIONALLICENCE 700 1- Strobl Karl Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany aut NATIONALLICENCE 700 1- Scholly Julia Medical and Surgical Epilepsy Units University of Strasbourg, Strasbourg, France aut NATIONALLICENCE 700 1- Steinhoff Bernhard Kork Epilepsy Centre, Landstrasse 1, 77694, Kehl-Kork, Germany aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/1(2015-01-01), 57-61 0001-6268 157:1<57 2015 157 701