caa a22 4500 606213570 CHVBK 20210128101048.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00701-014-2276-5 doi (NATIONALLICENCE)springer-10.1007/s00701-014-2276-5 Mouse cerebral magnetic resonance imaging fails to visualize brain volume changes after experimental subarachnoid hemorrhage [Elektronische Daten] [Etienne Atangana, David Homburg, Peter Vajkoczy, Ulf Schneider] Background: Brain atrophy after subarachnoid hemorrhage (SAH) has been detected in humans and might serve as a functional read-out parameter for neuropsychological deficits. To determine whether serial magnetic resonance imaging (MRI) can provide information on brain atrophy in animals as well, mice that had undergone experimental SAH were scanned repeatedly after the bleeding. Methods: Using a 7-T rodent MRI, six mice were evaluated for total hemispheric, cerebrospinal fluid (CSF) and hippocampal volumes on days 1, 2, 4, 21, 28, 42 and 60 after experimental SAH or sham operation, respectively. Results: Repeated MRI scanning demonstrated a very high reproducibility with minimum standard deviation. Nevertheless, no significant differences were found between the two groups concerning hemispherical volumes or hippocampal volumes. A transient but significant increase in CSF volume was detected on days 2 and 60 after SAH. Compared with the existing method, no MRI data on brain atrophy in mice after experimental SAH have been published. Conclusion: Repeated brain MRI in mice after experimental SAH did not provide additional information on brain atrophy. Our data suggest that this is not due to a lack of sensitivity of the method. Despite all promising details about MRI, our results should initiate careful consideration (additional sequences/other questions) before its further use in this certain area, especially since it is expensive and associated with demanding logistics. Springer-Verlag Wien, 2014 Brain atrophy nationallicence Subarachnoid hemorrhage nationallicence 7-T rodent magnetic resonance imaging nationallicence Hippocampus atrophy nationallicence Atangana Etienne Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany aut Homburg David Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany aut Vajkoczy Peter Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany aut Schneider Ulf Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany aut Acta Neurochirurgica Springer Vienna 157/1(2015-01-01), 37-42 0001-6268 157:1<37 2015 157 701 https://doi.org/10.1007/s00701-014-2276-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-014-2276-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Atangana Etienne Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 700 1- Homburg David Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 700 1- Vajkoczy Peter Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 700 1- Schneider Ulf Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/1(2015-01-01), 37-42 0001-6268 157:1<37 2015 157 701