caa a22 4500 606213643 CHVBK 20210128101048.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00701-015-2395-7 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2395-7 Fluorescein sodium-guided resection of cerebral metastases—experience with the first 30 patients [Elektronische Daten] [Karl-Michael Schebesch, Julius Hoehne, Christoph Hohenberger, Martin Proescholdt, Markus Riemenschneider, Christina Wendl, Alexander Brawanski] Background: Surgical resection is a key element of the multidisciplinary treatment of cerebral metastases (CMs). Recent studies have highlighted the importance of complete resection of CMs for improving recurrence-free and overall survival rates. This study presents the first data on the use of fluorescein sodium (FL) under the dedicated surgical microscope filter YELLOW 560nm (Zeiss Meditec, Germany) in patients with CM. Methods: Thirty patients with CMs of different primary cancers were included (15 females, 15 males; mean age 61.1years); 200mg of FL was intravenously injected directly before CM resection. A YELLOW 560nm filter was used for microsurgical tumor resection and resection control. Surgical reports were evaluated regarding the degree of fluorescent staining, postoperative MRIs regarding the extent of resection [gadolinium (Gd)-enhanced T1-weighted sequence] and the postoperative courses regarding any adverse effects. Results: Most patients (90.0%, n = 27) showed bright fluorescent staining, which markedly enhanced tumor visibility. Three patients (10.0%) (two with adenocarcinoma of the lung and one with melanoma of the skin) showed no or only insufficient FL staining. Another three patients (10.0%) showed residual tumor tissue in the postoperative MRI examination. In two other patients, radiographic examination could not exclude the possibility of very small areas of residual tumor tissue. Thus, gross-total resection was achieved in 83.3% (n = 25) of patients. No adverse effects were registered over the postoperative course. Conclusions: FL and the YELLOW 560nm filter are safe and practical tools for the resection of CM, but further prospective research is needed to confirm that this advanced technique will improve the quality of CM resection. Springer-Verlag Wien, 2015 Fluorescein sodium nationallicence YELLOW 560nm filter nationallicence Cerebral metastases nationallicence PENTERO 900 nationallicence Surgical microscope nationallicence Fluorescence-guided surgery nationallicence Neurosurgery nationallicence Schebesch Karl-Michael Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut Hoehne Julius Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut Hohenberger Christoph Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut Proescholdt Martin Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut Riemenschneider Markus Institute of Neuropathology, University Medical Center Regensburg, Regensburg, Germany aut Wendl Christina Institute of Radiology, Neuroradiology Branch, University Medical Center Regensburg, Regensburg, Germany aut Brawanski Alexander Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut Acta Neurochirurgica Springer Vienna 157/6(2015-06-01), 899-904 0001-6268 157:6<899 2015 157 701 https://doi.org/10.1007/s00701-015-2395-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2395-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schebesch Karl-Michael Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Hoehne Julius Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Hohenberger Christoph Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Proescholdt Martin Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Riemenschneider Markus Institute of Neuropathology, University Medical Center Regensburg, Regensburg, Germany aut NATIONALLICENCE 700 1- Wendl Christina Institute of Radiology, Neuroradiology Branch, University Medical Center Regensburg, Regensburg, Germany aut NATIONALLICENCE 700 1- Brawanski Alexander Department of Neurosurgery, University Medical Center Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Germany aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/6(2015-06-01), 899-904 0001-6268 157:6<899 2015 157 701