caa a22 4500 606213805 CHVBK 20210128101049.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00701-015-2394-8 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2394-8 Preemptive scalp infiltration with 0.5% ropivacaine and 1% lidocaine reduces postoperative pain after craniotomy [Elektronische Daten] [Jie Song, Li Li, Pengtao Yu, Tao Gao, Kui Liu] Background: In order to reduce the consequences of narcotic-related side effects and provide effective analgesia after craniotomy, we conducted a randomized trial to compare the analgesic efficacy of preemptive scalp infiltrations with 1% lidocaine and 0.5% ropivacaine on the postoperative pain. Methods: Sixty adult patients scheduled for craniotomy were enrolled. A solution contained 0.5% ropivacaine and 1% lidocaine (40ml) was prepared. In group A, local anesthetic was injected throughout the entire thickness of the scalp before skin incision. In group B, it was injected before skin closure. Additional intravenous injection and patient-controlled analgesia with morphine was used to control postoperative pain if the verbal numerical rating scale > 4. Cumulative morphine consumption; numerical rating scale of pain at 1, 2, 4, 6, 8, 12, and 24h; postoperative nausea, vomiting, and respiratory depression, were recorded for 24h after the operation. Results: Postoperative pain scores were lower in group A than in group B within the first 6h after surgery. Mean time to demand for postoperative analgesic was statistically (p < 0.001) delayed in group A 300 (240, 360) min compared to group B 150 (105, 200) min. Ten patients in group A received morphine analgesia was half less than 21 patients in group B (p < 0.006). The median morphine consumption in 24h after operation in group A 10.5 (8, 15) mg was less than that in group B 28 (22.5, 30.5) mg (p < 0.001). Conclusions: Preemptive scalp infiltration with 0.5% ropivacaine and 1% lidocaine provides effective postoperative analgesia after craniotomy. Springer-Verlag Wien, 2015 Preemptive analgesia nationallicence Scalp infiltration nationallicence Ropivacaine nationallicence Craniotomy nationallicence Song Jie Departments of Neurological Surgery, Union Medical Center, Tianjin, China aut Li Li Departments of Anesthesiology, Union Medical Center, 190#, Jieyuan Road, Hongqiao District, 300121, Tianjin, China aut Yu Pengtao Departments of Neurological Surgery, Union Medical Center, Tianjin, China aut Gao Tao Departments of Anesthesiology, Union Medical Center, 190#, Jieyuan Road, Hongqiao District, 300121, Tianjin, China aut Liu Kui Departments of Neurological Surgery, Union Medical Center, Tianjin, China aut Acta Neurochirurgica Springer Vienna 157/6(2015-06-01), 993-998 0001-6268 157:6<993 2015 157 701 https://doi.org/10.1007/s00701-015-2394-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2394-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Song Jie Departments of Neurological Surgery, Union Medical Center, Tianjin, China aut NATIONALLICENCE 700 1- Li Li Departments of Anesthesiology, Union Medical Center, 190#, Jieyuan Road, Hongqiao District, 300121, Tianjin, China aut NATIONALLICENCE 700 1- Yu Pengtao Departments of Neurological Surgery, Union Medical Center, Tianjin, China aut NATIONALLICENCE 700 1- Gao Tao Departments of Anesthesiology, Union Medical Center, 190#, Jieyuan Road, Hongqiao District, 300121, Tianjin, China aut NATIONALLICENCE 700 1- Liu Kui Departments of Neurological Surgery, Union Medical Center, Tianjin, China aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/6(2015-06-01), 993-998 0001-6268 157:6<993 2015 157 701