caa a22 4500 606213899 CHVBK 20210128101049.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00701-015-2415-7 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2415-7 Longitudinal FDG microPET imaging of neuropathic pain: does cerebellar activity correlate with neuropathic pain development in a rat model? [Elektronische Daten] [Jinhyung Kim, Jaewoo Shin, Jin-Hwan Oh, Hyun Jung, Young-Bo Kim, Zang-Hee Cho, Jin Chang] Background: We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. Methods: Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1week before operation and then weekly for 8weeks post-operation. Results: The behavioral test was performed immediately after the every FDG administration. After TST modeling, neuropathic pain rats showed increased mechanical sensitivity of the injured hind paw. The withdrawal response to mechanical pain stimulation by von Frey filaments was observed within the first week (3.8 ± 0.73), and it rapidly increased in the third week (7.13 ± 0.82). This response reached a peak in the fourth week after surgery (9.0 ± 0.53), which persisted until the eighth week. In microPET scan imaging, cerebellum, which initially started from the ansiform lobule, was activated gradually to all part from the third week in all image acquisitions through the eighth week. Conclusions: The longitudinal microPET scan study of brains from neuropathic pain rat models showed sequential cerebellar activity that was in accordance with results from behavioral test responses, thus supporting a role for the cerebellum in the development of neuropathic pain. Springer-Verlag Wien, 2015 Neuropathic pain nationallicence microPET nationallicence FDG nationallicence Cerebellum nationallicence Neuromodulation nationallicence Kim Jinhyung Brain Korea 21 Project for Medical Science and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea aut Shin Jaewoo Brain Korea 21 Project for Medical Science and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea aut Oh Jin-Hwan Neuroscience Research Institute, Gachon University, Incheon, Korea aut Jung Hyun Department of Neurosurgery, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut Kim Young-Bo Neuroscience Research Institute, Gachon University, Incheon, Korea aut Cho Zang-Hee Neuroscience Research Institute, Gachon University, Incheon, Korea aut Chang Jin Brain Korea 21 Project for Medical Science and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea aut Acta Neurochirurgica Springer Vienna 157/6(2015-06-01), 1051-1057 0001-6268 157:6<1051 2015 157 701 https://doi.org/10.1007/s00701-015-2415-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2415-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Jinhyung Brain Korea 21 Project for Medical Science and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Shin Jaewoo Brain Korea 21 Project for Medical Science and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Oh Jin-Hwan Neuroscience Research Institute, Gachon University, Incheon, Korea aut NATIONALLICENCE 700 1- Jung Hyun Department of Neurosurgery, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Young-Bo Neuroscience Research Institute, Gachon University, Incheon, Korea aut NATIONALLICENCE 700 1- Cho Zang-Hee Neuroscience Research Institute, Gachon University, Incheon, Korea aut NATIONALLICENCE 700 1- Chang Jin Brain Korea 21 Project for Medical Science and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/6(2015-06-01), 1051-1057 0001-6268 157:6<1051 2015 157 701