caa a22 4500 606214097 CHVBK 20210128101051.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00701-015-2495-4 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2495-4 Intracranial meningiomas and seizures: a review of the literature [Elektronische Daten] [Hai Xue, Olafur Sveinsson, Torbjörn Tomson, Tiit Mathiesen] Background: Seizures are a common manifestation of brain tumors, but literature on the incidence of seizures before and after surgery for meningiomas is limited, and principles for use of antiepileptic drugs (AEDs) are controversial. Methods: This review is based on a MEDLINE search for articles from 1994 to 2014 describing intracranial meningioma and seizures or epilepsy, and AEDs treatment during and after surgery. Results: Up to 40% of patients with symptomatic meningiomas present with seizures before operation. Tumor removal usually results in seizure control, but around 20% of patients continue to have or develop new-onset seizures after surgery. Risk factors for seizures after surgery include preoperative seizures, tumor location, and extent of tumor removal. There are no solid data to support routine pre- or postoperative AED prophylaxis in seizure-free patients, and the decision to treat and the selection of AEDs should follow the general principles of treatment of focal epilepsies. Conclusions: Seizures are a common manifestation of meningiomas, but about 80% patients with preoperative seizures can be seizure free after tumor removal. Prospective controlled AED trials specifically on meningioma patients are much needed. Springer-Verlag Wien, 2015 Meningioma nationallicence Seizures nationallicence Epilepsy nationallicence Risk factors nationallicence Antiepileptic Drugs nationallicence Xue Hai Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China aut Sveinsson Olafur Department of Neurology, Karolinska Hospital, Stockholm, Sweden aut Tomson Torbjörn Department of Clinical Neuroloscience, Karolinska Institute, Stockholm, Sweden aut Mathiesen Tiit Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden aut Acta Neurochirurgica Springer Vienna 157/9(2015-09-01), 1541-1548 0001-6268 157:9<1541 2015 157 701 https://doi.org/10.1007/s00701-015-2495-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2495-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xue Hai Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China aut NATIONALLICENCE 700 1- Sveinsson Olafur Department of Neurology, Karolinska Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Tomson Torbjörn Department of Clinical Neuroloscience, Karolinska Institute, Stockholm, Sweden aut NATIONALLICENCE 700 1- Mathiesen Tiit Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/9(2015-09-01), 1541-1548 0001-6268 157:9<1541 2015 157 701