caa a22 4500 606214178 CHVBK 20210128101051.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00701-015-2498-1 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2498-1 Anterior thalamic nucleus deep brain Stimulation (DBS) for drug-resistant complexpartial seizures (CPS) with or without generalization: long-term evaluation and predictive outcome [Elektronische Daten] [Massimo Piacentino, Christine Durisotti, Pier Garofalo, Paolo Bonanni, Anna Volzone, Federica Ranzato, Giacomo Beggio] Background: Drug-resistant epileptic patients account for 40% of cases of epilepsy. Consequently, specific therapeutic options could be surgical resection or, if not indicated, deep brain stimulation (DBS). The aim of this study is to review data from patients affected by drug-resistant complex partial epilepsy with or without generalization treated by anterior thalamic nucleus (AN) DBS to evaluate the efficacy and potential future applications of this approach as a standard method for palliative seizure control. Methods: Six patients affected by drug-resistant complexpartial seizures underwent AN DBS from March 2007 to February 2011. The preoperative tests consisted of electroencephalography (EEG), video EEG, morphologic and functional magnetic resonance imaging (MRI), non-acute positron emission tomography (PET), neuropsychological evaluation, Liverpool seizure scale, and Quality Of Life In Epilepsy (QOLIE). These tests and a seizure diary were also administered during a follow-up of at least 3years. Results: The improvement in terms of decrease of seizures was more than 50% in patients affected by complexpartial seizures strictly related to limbic system origin. The amelioration was unsatisfactory for patients having anatomical lesions outside the limbic structures with evidence of late diffusion in limbic areas. One patient died 40days after surgery for reasons not concerned with DBS. Conclusions: Although the limited number of enrolled patients limits the reliability of data, the results are in accordance with those found in the recent literature and deserve to be considered for further studies regarding real efficacy, indications, stimulation parameters, side effects, and complications. Springer-Verlag Wien, 2015 Drug-resistant epilepsy nationallicence Deep brain stimulation nationallicence Anterior thalamic nucleus nationallicence AN DBS nationallicence Palliative seizure control nationallicence Piacentino Massimo Department of Neurosurgery, San Bortolo Hospital, Viale Rodolfi, 37-36100, Vicenza, Italy aut Durisotti Christine Department of Neurology, San Bortolo Hospital, Vicenza, Italy aut Garofalo Pier Department of Neurology, San Bortolo Hospital, Vicenza, Italy aut Bonanni Paolo IRCS La Nostra Famiglia, Conegliano, Italy aut Volzone Anna IRCS La Nostra Famiglia, Conegliano, Italy aut Ranzato Federica Department of Neurology, San Bortolo Hospital, Vicenza, Italy aut Beggio Giacomo Department of Neurosurgery, San Bortolo Hospital, Viale Rodolfi, 37-36100, Vicenza, Italy aut Acta Neurochirurgica Springer Vienna 157/9(2015-09-01), 1525-1532 0001-6268 157:9<1525 2015 157 701 https://doi.org/10.1007/s00701-015-2498-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2498-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Piacentino Massimo Department of Neurosurgery, San Bortolo Hospital, Viale Rodolfi, 37-36100, Vicenza, Italy aut NATIONALLICENCE 700 1- Durisotti Christine Department of Neurology, San Bortolo Hospital, Vicenza, Italy aut NATIONALLICENCE 700 1- Garofalo Pier Department of Neurology, San Bortolo Hospital, Vicenza, Italy aut NATIONALLICENCE 700 1- Bonanni Paolo IRCS La Nostra Famiglia, Conegliano, Italy aut NATIONALLICENCE 700 1- Volzone Anna IRCS La Nostra Famiglia, Conegliano, Italy aut NATIONALLICENCE 700 1- Ranzato Federica Department of Neurology, San Bortolo Hospital, Vicenza, Italy aut NATIONALLICENCE 700 1- Beggio Giacomo Department of Neurosurgery, San Bortolo Hospital, Viale Rodolfi, 37-36100, Vicenza, Italy aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/9(2015-09-01), 1525-1532 0001-6268 157:9<1525 2015 157 701