caa a22 4500 606214410 CHVBK 20210128101053.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00701-015-2427-3 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2427-3 Primary pineal malignant melanoma with B-Raf V600E mutation: a case report and brief review of the literature [Elektronische Daten] [Kathleen Jetschke, Heike Viehweger, Martin Freesmeyer, Jan-Peter Warnke, Christian Mawrin] Primary pineal melanoma is exceedingly rare, and sufficient treatment options have not been established. Here we describe a 57-year-old male patient who presented with short-term memory disturbance and ataxia. Magnetic resonance imaging of the brain showed a tumor mass in the pineal gland. Biopsy revealed a malignant melanocytic tumor. No primary malignant melanoma was known, and extensive imaging studies including PET-CT excluded other sites affected by a malignant melanoma. The demonstration of the BRAF V600E mutation in the pineal tumor made the patient eligible for intrathecal treatment with vemurafenib. Unfortunately, the patient died 26days after surgery due to tumor hemorrhage. This is the first report of V600E in primary pineal melanoma, suggesting that a fraction of these rare tumors might additionally benefit from vemurafenib treatment. Springer-Verlag Wien, 2015 BRAF nationallicence Melanoma nationallicence Pineal nationallicence Jetschke Kathleen Department of Neurosurgery, Paracelsus-Hospital Zwickau, Zwickau, Germany aut Viehweger Heike Department of Diagnostic Radiology, Paracelsus-Hospital Zwickau, Zwickau, Germany aut Freesmeyer Martin Department of Nuclear Medicine, Friedrich-Schiller-University Jena, Jena, Germany aut Warnke Jan-Peter Department of Neurosurgery, Paracelsus-Hospital Zwickau, Zwickau, Germany aut Mawrin Christian Department of Neuropathology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany aut Acta Neurochirurgica Springer Vienna 157/7(2015-07-01), 1267-1270 0001-6268 157:7<1267 2015 157 701 https://doi.org/10.1007/s00701-015-2427-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2427-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jetschke Kathleen Department of Neurosurgery, Paracelsus-Hospital Zwickau, Zwickau, Germany aut NATIONALLICENCE 700 1- Viehweger Heike Department of Diagnostic Radiology, Paracelsus-Hospital Zwickau, Zwickau, Germany aut NATIONALLICENCE 700 1- Freesmeyer Martin Department of Nuclear Medicine, Friedrich-Schiller-University Jena, Jena, Germany aut NATIONALLICENCE 700 1- Warnke Jan-Peter Department of Neurosurgery, Paracelsus-Hospital Zwickau, Zwickau, Germany aut NATIONALLICENCE 700 1- Mawrin Christian Department of Neuropathology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/7(2015-07-01), 1267-1270 0001-6268 157:7<1267 2015 157 701