caa a22 4500 606214534 CHVBK 20210128101053.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00701-015-2614-2 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2614-2 Long-term outcomes in patients with pineal nongerminomatous malignant germ cell tumors treated by radical resection during initial treatment combined with adjuvant therapy [Elektronische Daten] [Shinya Jinguji, Junichi Yoshimura, Kenichi Nishiyama, Yuichiro Yoneoka, Masakazu Sano, Masafumi Fukuda, Yukihiko Fujii] Background: For pineal nongerminomatous malignant germ cell tumors (NGMGCTs), we mainly performed radical tumor resection during initial treatment combined with adjuvant therapy. Methods: We retrospectively analyzed 17 patients treated for pineal NGMGCTs between 1986 and 2007 at the University of Niigata. Results: Twelve patients underwent total or subtotal resection of their tumor via the occipital transtentorial approach. Five patients underwent partial resection, and four of them later underwent total resection by salvage surgery. After surgery, eight patients were treated with combined radiochemotherapy including whole-brain irradiation, two received radiation monotherapy, one had chemotherapy with local irradiation, and six were treated with chemotherapy alone. The median follow-up period for surviving patients was 179months. The 10-year overall survival and progression-free survival rates for the radiochemotherapy group were both 75.0% (two patients had a recurrence and died); the rates for other adjuvant therapies were 77.8% (two died) and 22.2% (seven had a recurrence), respectively. Radiochemotherapy was significantly associated with an increased rate of progression-free survival compared with the other adjuvant therapies (p = 0.0396). Conclusions: For pineal NGMGCTs, initial treatment strategies including gross total resection of the tumor before or after whole-brain irradiation and chemotherapy provided good therapeutic outcomes. Obtaining complete remission of the primary tumor, irrespective of the timing of surgical resection (i.e., before or after adjuvant therapies), or complete response by neoadjuvant radiochemotherapy during an initial treatment appears to be essential for improving therapeutic outcomes of intracranial NGMGCTs. Springer-Verlag Wien, 2015 Brain tumor nationallicence Intracranial germ cell tumor nationallicence Nongerminomatous germ cell tumor nationallicence Occipital transtentorial approach nationallicence Pineal tumor nationallicence Jinguji Shinya Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut Yoshimura Junichi Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut Nishiyama Kenichi Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut Yoneoka Yuichiro Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut Sano Masakazu Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut Fukuda Masafumi Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut Fujii Yukihiko Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2175-2183 0001-6268 157:12<2175 2015 157 701 https://doi.org/10.1007/s00701-015-2614-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2614-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jinguji Shinya Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut NATIONALLICENCE 700 1- Yoshimura Junichi Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut NATIONALLICENCE 700 1- Nishiyama Kenichi Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut NATIONALLICENCE 700 1- Yoneoka Yuichiro Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut NATIONALLICENCE 700 1- Sano Masakazu Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut NATIONALLICENCE 700 1- Fukuda Masafumi Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut NATIONALLICENCE 700 1- Fujii Yukihiko Department of Neurosurgery, Brain Research Institute, University of Niigata, 1-757, Asahimachi-dori, Chuo-ku, 951-8585, Niigata City, Niigata, Japan aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2175-2183 0001-6268 157:12<2175 2015 157 701