caa a22 4500 606214577 CHVBK 20210128101054.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00701-015-2611-5 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2611-5 Clinical characteristics and follow-up of intracranial metastases from thyroid cancer [Elektronische Daten] [Heui Lee, Heon Yoo, Seung Lee, Ho Gwak, Sang Shin] Background: Intracranial metastasis from thyroid cancer is extremely rare. However, less is known about the risk factors for intracranial metastasis and its treatment from few retrospective studies. The aim of this study was to contribute to the understanding of this disease by analyzing patients with intracranial metastases from thyroid cancer. Methods: Between 2001 and 2014, the database of the National Cancer Center of Korea was searched for thyroid cancer patients. The clinical characteristics and site of distant metastasis according to the histological type were evaluated in the thyroid cancer cohort. Among the patients with intracranial metastases, the characteristics, histological type of primary cancer and metastatic brain tumor, additional synchronous or previous distant metastasis, treatment modalities, locations and characteristics on radiologic findings, time interval between the first diagnosis of the primary thyroid cancer and brain metastasis, thyroglobulin level at the first detection of intracranial metastasis and survival were reviewed. Results: A total of 10 (0.032%) out of 3,090 thyroid cancer patients in the National Cancer Center database were identified as having intracranial metastases. The histological types of the primary thyroid cancers were papillary for six patients, follicular for three, and poorly differentiated carcinoma for one. Six of these ten patients underwent surgical resection for intracranial lesions. Whole-brain radiotherapy or tyrosine kinase inhibitors were applied to the patients as postoperative adjuvant treatment, and stereotactic radiosurgery was considered for recurrent or surgically inoperable lesions. The overall median survival time was 33months (range, 0.5-78months) after diagnosis of intracranial metastasis. Conclusions: Surgical resection and adjuvant treatments in the contemporary era seem to result in improved survival after intracranial metastases compared with what has been reported in past studies. Considering the grave course of intracranial metastasis, the early detection and aggressive treatment of patients with a good performance status are crucial. Springer-Verlag Wien, 2015 Thyroid cancer nationallicence Metastasis nationallicence Brain nationallicence Skull nationallicence Papillary nationallicence Follicular nationallicence Anaplastic nationallicence Lee Heui Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea aut Yoo Heon Neuro-Oncology Clinic, National Cancer Center, Madu 1-dong, Ilsandong-gu, 410-769, Goyang, Korea aut Lee Seung Neuro-Oncology Clinic, National Cancer Center, Madu 1-dong, Ilsandong-gu, 410-769, Goyang, Korea aut Gwak Ho Neuro-Oncology Clinic, National Cancer Center, Madu 1-dong, Ilsandong-gu, 410-769, Goyang, Korea aut Shin Sang Neuro-Oncology Clinic, National Cancer Center, Madu 1-dong, Ilsandong-gu, 410-769, Goyang, Korea aut Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2185-2194 0001-6268 157:12<2185 2015 157 701 https://doi.org/10.1007/s00701-015-2611-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2611-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Heui Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Yoo Heon Neuro-Oncology Clinic, National Cancer Center, Madu 1-dong, Ilsandong-gu, 410-769, Goyang, Korea aut NATIONALLICENCE 700 1- Lee Seung Neuro-Oncology Clinic, National Cancer Center, Madu 1-dong, Ilsandong-gu, 410-769, Goyang, Korea aut NATIONALLICENCE 700 1- Gwak Ho Neuro-Oncology Clinic, National Cancer Center, Madu 1-dong, Ilsandong-gu, 410-769, Goyang, Korea aut NATIONALLICENCE 700 1- Shin Sang Neuro-Oncology Clinic, National Cancer Center, Madu 1-dong, Ilsandong-gu, 410-769, Goyang, Korea aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2185-2194 0001-6268 157:12<2185 2015 157 701