caa a22 4500 606214585 CHVBK 20210128101054.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00701-015-2615-1 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2615-1 Electrophysiological validation of STN-SNr boundary depicted by susceptibility-weighted MRI [Elektronische Daten] [J. McEvoy, Ismail Ughratdar, S. Schwarz, S. Basu] Background: Direct targeting of subthalamic nucleus (STN) without secondary electrophysiological verification during deep brain stimulation (DBS) is replacing atlas-based indirect targeting techniques. Recent groups have reported increased contrast and better delineation of STN and substantia nigra (SNr) in susceptibility-weighted imaging protocols (SWI). We aim to validate the STN-SNr boundary seen in MRI- SWI by correlating with intraoperative microelectrode recordings (MER) as a part of developing a multi-contrast DBS MRI planning protocol. Methods: Prospective service evaluation involving electrophysiological verification by correlation of MER trajectory and STN-SNr boundary seen in SWI in seven consecutive patients undergoing DBS surgery were analyzed. The angle of inclination of the STN-SNr boundary and DBS trajectory in the coronal plane were calculated. Considering 4-mm dispersion of a coronal 3 MER array, we predicted, measured, and correlated the depths at which each electrode engaged the boundary. Results: All central microelectrodes identified the STN-SNr boundary within 1mm of the predicted depth with 100% accuracy. Ninety percent of the lateral MER identified the STN-SNr boundary as predicted from SWI and angle of the encounter of the MER front. Conclusions: The study demonstrates that STN morphology can be depicted using SWI MRI and coincides reliably with the electrophysiological MER boundary. Thus, this imaging modality can be used to refine STN direct targeting protocols in DBS surgery for PD. Springer-Verlag Wien, 2015 Subthalamic nucleus nationallicence Substantia nigra nationallicence Deep brain stimulation nationallicence Parkinson's disease nationallicence Targeting nationallicence Susceptibility-weighted imaging nationallicence Magnetic resonance imaging nationallicence Microelectrode recording nationallicence Stereotactic surgery nationallicence McEvoy J. University of Nottingham Medical School, Nottingham, UK aut Ughratdar Ismail Department of Neurosurgery, Nottingham University Hospitals, Nottingham, UK aut Schwarz S. Department of Academic Radiology, University of Nottingham Medical School, Nottingham, UK aut Basu S. Department of Neurosurgery, Nottingham University Hospitals, Nottingham, UK aut Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2129-2134 0001-6268 157:12<2129 2015 157 701 https://doi.org/10.1007/s00701-015-2615-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2615-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McEvoy J. University of Nottingham Medical School, Nottingham, UK aut NATIONALLICENCE 700 1- Ughratdar Ismail Department of Neurosurgery, Nottingham University Hospitals, Nottingham, UK aut NATIONALLICENCE 700 1- Schwarz S. Department of Academic Radiology, University of Nottingham Medical School, Nottingham, UK aut NATIONALLICENCE 700 1- Basu S. Department of Neurosurgery, Nottingham University Hospitals, Nottingham, UK aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2129-2134 0001-6268 157:12<2129 2015 157 701