caa a22 4500 606214593 CHVBK 20210128101054.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00701-015-2599-x doi (NATIONALLICENCE)springer-10.1007/s00701-015-2599-x Deep brain stimulation of the subthalamic nucleus: histological verification and 9.4-T MRI correlation [Elektronische Daten] [Othman Al-Helli, David Thomas, Luke Massey, Thomas Foltynie, Patricia Limousin, Janice Holton, Tarek Yousry, Ludvic Zrinzo] Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using an MRI-guided and MRI-verified technique without microelectrode recording is an effective and safe surgical treatment for patients with Parkinson's disease (PD). Objectives: To assess the anatomical accuracy of lead placement after MRI-guided, MRI-verified STN DBS using post-mortem histology and high-field MRI at 9.4T. Methods: We conducted post-mortem analysis of a patient's brain who had had MRI-guided, MRI-verified STN DBS for PD, using 9.4-T MRI and histology. After death, the brain was retrieved and a block including the electrode tracks down to the mesencephalon was examined with high-field MRI at 9.4T and histological analysis. Results: High-field MRI images and corresponding histological examination showed that each electrode track ended within the intended target area, and that DBS did not cause significant neuroparenchymal tissue damage. Conclusions: This study supports the anatomical accuracy of the MRI-guided and MRI-verified method of STN DBS. Springer-Verlag Wien, 2015 Parkinson's disease nationallicence Deep brain stimulation nationallicence Subthalamic nucleus nationallicence Post-mortem nationallicence STN : Subthalamic nucleus nationallicence DBS : Deep brain stimulation nationallicence T : Tesla nationallicence PM : Post-mortem nationallicence PD : Parkinson's disease nationallicence AC : Anterior commissure nationallicence PC : Posterior commissure nationallicence Al-Helli Othman Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, WC1n 3BG, London, UK aut Thomas David Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, WC1n 3BG, London, UK aut Massey Luke Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK aut Foltynie Thomas Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK aut Limousin Patricia Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK aut Holton Janice Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, London, UK aut Yousry Tarek Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, WC1n 3BG, London, UK aut Zrinzo Ludvic Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK aut Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2143-2147 0001-6268 157:12<2143 2015 157 701 https://doi.org/10.1007/s00701-015-2599-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2599-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Al-Helli Othman Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, WC1n 3BG, London, UK aut NATIONALLICENCE 700 1- Thomas David Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, WC1n 3BG, London, UK aut NATIONALLICENCE 700 1- Massey Luke Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK aut NATIONALLICENCE 700 1- Foltynie Thomas Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK aut NATIONALLICENCE 700 1- Limousin Patricia Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK aut NATIONALLICENCE 700 1- Holton Janice Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, London, UK aut NATIONALLICENCE 700 1- Yousry Tarek Neuroradiology Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, 8-11 Queen Square, WC1n 3BG, London, UK aut NATIONALLICENCE 700 1- Zrinzo Ludvic Unit of Functional Neurosurgery, UCL Institute of Neurology, London, UK aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2143-2147 0001-6268 157:12<2143 2015 157 701