caa a22 4500 606214712 CHVBK 20210128101055.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00701-015-2613-3 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2613-3 Thoracic shock wave injury causes behavioral abnormalities in mice [Elektronische Daten] [Hiromi Miyazaki, Hiroki Miyawaki, Yasushi Satoh, Takami Saiki, Satoko Kawauchi, Shunichi Sato, Daizoh Saitoh] Background: Mild traumatic brain injury (mTBI) is caused by complex mechanisms of systemic, local and cerebral responses to blast exposure. However, the molecular mechanisms of cognitive impairment after exposure to blast waves are not clearly known. We tested the hypothesis that thoracic injury induced functional and morphological impairment in the brain, leading to behavioral abnormalities. Methods: Mice were exposed to laser-induced shock waves (LISWs) impacting the thorax and assessed for behavioral outcome at 7 and 28days post injury. Hippocampus and lung were collected for histopathological analysis and gene expression profiling after injury. Results: Thoracic injury transiently decreased the heart rate, blood pressure, peripheral oxyhemoglobin saturation and cerebral blood flow immediately after LISW exposure. Although LISWs exposure caused pulmonary contusions, hemorrhage was not apparent in the brain. At 7 and 28days after, the injured mice exhibited impaired short-term memory and depression-like behavior compared with controls. Histological assessments showed an increase in neuronal cell death after shock wave exposure, especially in the CA3 region of the hippocampus. Moreover, shock wave exposure altered the expression of functionally relevant genes in the hippocampus at 1h and 1day post injury. Conclusions: Our findings indicate that the LISW-induced thoracic injury with no direct impact on the brain affected the hippocampal gene expression and led to morphological alterations, resulting in behavioral abnormalities. Therefore, body protection may be extremely important in the effective prevention against blast-induced alterations in brain function. Springer-Verlag Wien, 2015 Shock waves nationallicence Thoracic injury nationallicence Hippocampus nationallicence Cognitive dysfunction nationallicence Miyazaki Hiromi Division of Traumatology, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut Miyawaki Hiroki Department of Traumatology and Critical Care Medicine, National Defense Medical College Hospital, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut Satoh Yasushi Department of Anesthesiology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut Saiki Takami Division of Traumatology, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut Kawauchi Satoko Division of Biomedical Information Sciences, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut Sato Shunichi Division of Biomedical Information Sciences, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut Saitoh Daizoh Division of Traumatology, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2111-2120 0001-6268 157:12<2111 2015 157 701 https://doi.org/10.1007/s00701-015-2613-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2613-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miyazaki Hiromi Division of Traumatology, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Miyawaki Hiroki Department of Traumatology and Critical Care Medicine, National Defense Medical College Hospital, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Satoh Yasushi Department of Anesthesiology, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Saiki Takami Division of Traumatology, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Kawauchi Satoko Division of Biomedical Information Sciences, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Sato Shunichi Division of Biomedical Information Sciences, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Saitoh Daizoh Division of Traumatology, Research Institute, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/12(2015-12-01), 2111-2120 0001-6268 157:12<2111 2015 157 701