caa a22 4500 606215123 CHVBK 20210128101057.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00701-014-2328-x doi (NATIONALLICENCE)springer-10.1007/s00701-014-2328-x Accuracy of subthalamic nucleus targeting by T2, FLAIR and SWI-3-Tesla MRI confirmed by microelectrode recordings [Elektronische Daten] [Witold Polanski, Klaus Martin, Kay Engellandt, Rüdiger von Kummer, Lisa Klingelhoefer, Mareike Fauser, Alexander Storch, Gabriele Schackert, Stephan Sobottka] Background: Successful deep brain stimulation is mostly dependent on accurate positioning of the leads at the optimal target points. We investigated whether the identification of the subthalamic nucleus in T2-weighted 3-T MRI, fluid-attenuated inversion recovery 3-T MRI and susceptibility-weighted 3-T MRI is confirmed by intraoperative neurological microelectrode recording. Methods: We evaluated 182 microelectrode recording leads in 21 patients with bilateral deep brain stimulation, retrospectively. Consequently, 728 electrode contact positions in T2-weighted 3-T MRI, 552 electrode contact positions in fluid-attenuated inversion recovery 3-T MRI and 490 electrode contact positions in susceptibility-weighted 3-T MRI were evaluated for a positive nucleus subthalamicus signal. Results: The highest sensitivity was measured for fluid-attenuated inversion recovery 3-T MRI with 82.5%, while the highest specificity was observed for susceptibility-weighted 3-T MRI with 90.6%. The negative predictive value was nearly equal for susceptibility-weighted MRI and fluid-attenuated inversion recovery MRI with 87.5% vs. 87.1%, but the positive predictive value was higher in susceptibility-weighted 3-T MRI (86.0%) than in the other MRI sequences. Conclusions: The susceptibility-weighted 3-T MRI-based subthalamic nucleus localization shows the best accuracy compared with T2-weighted and fluid-attenuated inversion recovery 3-T MRI. Therefore, the susceptibility-weighted 3-T MRI should be preferred for surgical planning when the operation procedure is performed under general anesthesia without microelectrode recordings. Springer-Verlag Wien, 2015 Deep brain stimulation nationallicence Subthalamic nucleus nationallicence Parkinson's disease nationallicence MRI nationallicence Intraoperative microelectrode recording nationallicence Polanski Witold Department of Neurosurgery, Medical school ‘Carl Gustav Carus' of the Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany aut Martin Klaus Department of Neurosurgery, Medical school ‘Carl Gustav Carus' of the Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany aut Engellandt Kay Department of Neuroradiology, Technical University of Dresden, Dresden, Germany aut von Kummer Rüdiger Department of Neuroradiology, Technical University of Dresden, Dresden, Germany aut Klingelhoefer Lisa Division of Neurodegenerative Diseases, Department of Neurology, Technical University of Dresden, Dresden, Germany aut Fauser Mareike Division of Neurodegenerative Diseases, Department of Neurology, Technical University of Dresden, Dresden, Germany aut Storch Alexander Division of Neurodegenerative Diseases, Department of Neurology, Technical University of Dresden, Dresden, Germany aut Schackert Gabriele Department of Neurosurgery, Medical school ‘Carl Gustav Carus' of the Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany aut Sobottka Stephan Department of Neurosurgery, Medical school ‘Carl Gustav Carus' of the Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany aut Acta Neurochirurgica Springer Vienna 157/3(2015-03-01), 479-486 0001-6268 157:3<479 2015 157 701 https://doi.org/10.1007/s00701-014-2328-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-014-2328-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Polanski Witold Department of Neurosurgery, Medical school ‘Carl Gustav Carus' of the Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Martin Klaus Department of Neurosurgery, Medical school ‘Carl Gustav Carus' of the Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Engellandt Kay Department of Neuroradiology, Technical University of Dresden, Dresden, Germany aut NATIONALLICENCE 700 1- von Kummer Rüdiger Department of Neuroradiology, Technical University of Dresden, Dresden, Germany aut NATIONALLICENCE 700 1- Klingelhoefer Lisa Division of Neurodegenerative Diseases, Department of Neurology, Technical University of Dresden, Dresden, Germany aut NATIONALLICENCE 700 1- Fauser Mareike Division of Neurodegenerative Diseases, Department of Neurology, Technical University of Dresden, Dresden, Germany aut NATIONALLICENCE 700 1- Storch Alexander Division of Neurodegenerative Diseases, Department of Neurology, Technical University of Dresden, Dresden, Germany aut NATIONALLICENCE 700 1- Schackert Gabriele Department of Neurosurgery, Medical school ‘Carl Gustav Carus' of the Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Sobottka Stephan Department of Neurosurgery, Medical school ‘Carl Gustav Carus' of the Technical University of Dresden, Fetscherstr. 74, 01307, Dresden, Germany aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/3(2015-03-01), 479-486 0001-6268 157:3<479 2015 157 701