caa a22 4500 606215174 CHVBK 20210128101057.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00701-015-2532-3 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2532-3 Growth stabilization and regression of meningiomas after discontinuation of cyproterone acetate: a case series of 12 patients [Elektronische Daten] [Anne Bernat, Kenichi Oyama, Selma Hamdi, Emmanuel Mandonnet, Dominique Vexiau, Marc Pocard, Bernard George, Sebastien Froelich] Background: The relationship between meningiomas and exogenous sex hormones is well known, but cyproterone acetate (CA), a progesterone agonist, seems to have a stronger influence on tumor growth. Objective: To show the close relationship between CA treatment and meningioma growth. Methods: Since 2010, all patients referred to our clinic for a suspicion of meningioma were questioned specifically about exogenous sex hormone intake and more specifically about CA intake. Twelve patients harboring one or multiple meningiomas and treated with CA were identified. CA was stopped in all cases. Tumor volumes and diameters were measured on serial MRIs and compared to the last MRI before CA withdrawal. Results: Ten patients with multiple tumors had been taking the drug for a longer period of time (mean of 20.4years) than the two patients with one tumor (10years). Two patients with multiple tumors underwent surgery because of rapidly decreased visual acuity at the time of diagnosis. Discontinuation of CA led to tumor shrinkage in 11 patients and a stop in tumor growth in one [mean tumor volume reduction was around 10cm3/year; range (0.00; 76)]. There was no regrowth during a mean follow-up period of 12months (range: 5-35). Conclusion: For patients diagnosed with a meningioma and treated with CA, medication withdrawal followed by observation should be the first line of treatment. Care should be taken with long-term use of high doses of CA, and serial brain MRIs should be considered after several years of CA. Springer-Verlag Wien, 2015 Cyproterone acetate nationallicence Meningioma nationallicence Meningiomatosis nationallicence Progesterone agonist nationallicence Bernat Anne Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut Oyama Kenichi Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut Hamdi Selma Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut Mandonnet Emmanuel Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut Vexiau Dominique Department of Gynecology, Hôpital Lariboisière, Paris, France aut Pocard Marc Department of Visceral Surgery, Hôpital Lariboisière, Paris, France aut George Bernard Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut Froelich Sebastien Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut Acta Neurochirurgica Springer Vienna 157/10(2015-10-01), 1741-1746 0001-6268 157:10<1741 2015 157 701 https://doi.org/10.1007/s00701-015-2532-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2532-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bernat Anne Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut NATIONALLICENCE 700 1- Oyama Kenichi Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut NATIONALLICENCE 700 1- Hamdi Selma Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut NATIONALLICENCE 700 1- Mandonnet Emmanuel Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut NATIONALLICENCE 700 1- Vexiau Dominique Department of Gynecology, Hôpital Lariboisière, Paris, France aut NATIONALLICENCE 700 1- Pocard Marc Department of Visceral Surgery, Hôpital Lariboisière, Paris, France aut NATIONALLICENCE 700 1- George Bernard Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut NATIONALLICENCE 700 1- Froelich Sebastien Department of Neurosurgery, Hôpital Lariboisière, Paris VII-Diderot University, 2 rue Ambroise Pare, 75475, Paris, France aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/10(2015-10-01), 1741-1746 0001-6268 157:10<1741 2015 157 701