caa a22 4500 606215492 CHVBK 20210128101059.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00701-015-2353-4 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2353-4 Phase-shift between arterial flow and ICP pulse during infusion test [Elektronische Daten] [Dong-Joo Kim, Marek Czosnyka, Hakseung Kim, Olivier Balédent, Piotr Smielewski, Matthew Garnett, Zofia Czosnyka] Background: The dynamic relationship between pulse waveform of intracranial pressure (ICP) and transcranial Doppler (TCD) cerebral blood flow velocity (CBFV) may contain information about cerebrospinal compliance. This study investigated the possibility by focusing on the phase shift between fundamental harmonics of CBFV and ICP. Methods: Thirty-seven normal pressure hydrocephalus patients (20 men, mean age 58) underwent the cerebrospinal fluid (CSF) infusion tests. The infusion was performed via pre-implanted Ommaya reservoir. The TCD FV was recorded in the middle cerebral artery. Resulting continuous ICP and pressure-volume (PV) signals were analyzed by ICM+ software. Results: In initial stage of the CSF infusion, the phase shift was negative (median value = −11°, range = +60 to −117). There was significant inverse association of phase shift with brain elasticity (R = −0.51; p = 0.0009). In all tests, phase shift consistently decreased during gradual elevation of ICP (p = 0.00001). Magnitude of decrease in phase shift was inversely related to the peak-to-peak amplitude of ICP pulse waveform at a baseline (R = −0.51; p = 0.001). Conclusions: Phase shift between fundamental harmonics of ICP and TCD waveforms decreases during elevation of ICP. This is caused by an increase of time delay between systolic peak of flow velocity wave and ICP pulse. Springer-Verlag Wien, 2015 Cerebrospinal compliance nationallicence Intracranial pressure nationallicence Transcranial Doppler nationallicence Kim Dong-Joo Departments of Brain and Cognitive Engineering, Korea University, Anam-dong, Seongbu-gu, 136-713, Seoul, South Korea aut Czosnyka Marek Academic Neurosurgical Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK aut Kim Hakseung Departments of Brain and Cognitive Engineering, Korea University, Anam-dong, Seongbu-gu, 136-713, Seoul, South Korea aut Balédent Olivier Department of Biophysics and Medical Image Processing, Center Hospital University Amiens, Amiens, France aut Smielewski Piotr Academic Neurosurgical Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK aut Garnett Matthew Division of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK aut Czosnyka Zofia Academic Neurosurgical Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK aut Acta Neurochirurgica Springer Vienna 157/4(2015-04-01), 633-638 0001-6268 157:4<633 2015 157 701 https://doi.org/10.1007/s00701-015-2353-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2353-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Dong-Joo Departments of Brain and Cognitive Engineering, Korea University, Anam-dong, Seongbu-gu, 136-713, Seoul, South Korea aut NATIONALLICENCE 700 1- Czosnyka Marek Academic Neurosurgical Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK aut NATIONALLICENCE 700 1- Kim Hakseung Departments of Brain and Cognitive Engineering, Korea University, Anam-dong, Seongbu-gu, 136-713, Seoul, South Korea aut NATIONALLICENCE 700 1- Balédent Olivier Department of Biophysics and Medical Image Processing, Center Hospital University Amiens, Amiens, France aut NATIONALLICENCE 700 1- Smielewski Piotr Academic Neurosurgical Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK aut NATIONALLICENCE 700 1- Garnett Matthew Division of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK aut NATIONALLICENCE 700 1- Czosnyka Zofia Academic Neurosurgical Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/4(2015-04-01), 633-638 0001-6268 157:4<633 2015 157 701