caa a22 4500 60621593X CHVBK 20210128101101.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00701-015-2473-x doi (NATIONALLICENCE)springer-10.1007/s00701-015-2473-x Experiences with TachoSil® in microneurosurgery [Elektronische Daten] [Juri Kivelev, Felix Göhre, Mika Niemelä, Juha Hernesniemi] Background: We analyze our experience of using TachoSil® (Takeda Austria GmbH: Linz, Austria) in microneurosurgical procedures as a hemostat and also as a sealant to patch dural defects. Materials and methods: Beginning on January 1, 2012, we prospectively analyzed 100 consecutive surgeries where TachoSil was used. The patient group included 58 women (58%) and 42 men (42%); the mean age was 52years (range, 3-85 years). Indications for surgery included removal of the tumor (53 cases; 53%), clipping of the cerebral arterial aneurysm (31 cases; 31%), and treatment of other pathologies, including AVM (four cases; 4%), cavernomas (four cases; 4%), spinal tumor, and traumatic subdural hematoma. Patients received postoperative care according to local neurosurgical department protocol, including a postoperative CT scan after each craniotomy. Primary assessment of the wound took place during the hospital stay as well as at discharge or transfer to a rehabilitation unit. Mean follow-up time was 4months (range, 1-12 months). Results: None of the patients developed postoperative hematoma after craniotomy or spinal procedure. At primary assessment during hospital stay, 93 patients (93%) had had no wound-related problems over the normal course of healing. No case registered any liquor leak from the wound, and none of the patients showed any signs of allergic response related to TachoSil usage. At the last follow-up, 96 patients (96%) experienced uneventful wound healing, and in four patients (4%), superficial wound infection was successfully treated with oral antibiotics. Conclusions: Our results indicate that TachoSil can serve in neurosurgical practice at no additional risks. TachoSil proved to be an effective hemostat, sealant, and adhesive in either cranial or spinal procedures. Springer-Verlag Wien, 2015 Hemostats nationallicence Sealant nationallicence Adhesive nationallicence Neurosurgical wound nationallicence Kivelev Juri Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, 00260, Helsinki, Finland aut Göhre Felix Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, 00260, Helsinki, Finland aut Niemelä Mika Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, 00260, Helsinki, Finland aut Hernesniemi Juha Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, 00260, Helsinki, Finland aut Acta Neurochirurgica Springer Vienna 157/8(2015-08-01), 1353-1357 0001-6268 157:8<1353 2015 157 701 https://doi.org/10.1007/s00701-015-2473-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2473-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kivelev Juri Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, 00260, Helsinki, Finland aut NATIONALLICENCE 700 1- Göhre Felix Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, 00260, Helsinki, Finland aut NATIONALLICENCE 700 1- Niemelä Mika Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, 00260, Helsinki, Finland aut NATIONALLICENCE 700 1- Hernesniemi Juha Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Topeliuksenkatu 5, 00260, Helsinki, Finland aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/8(2015-08-01), 1353-1357 0001-6268 157:8<1353 2015 157 701