caa a22 4500 606216138 CHVBK 20210128101102.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00701-015-2367-y doi (NATIONALLICENCE)springer-10.1007/s00701-015-2367-y Morphology and related hemodynamics of the internal carotid arteries of moyamoya patients [Elektronische Daten] [Tackeun Kim, Jae Bang, O-Ki Kwon, Gyojun Hwang, Jeong Kim, Hyun-Seung Kang, Won Cho, Jong Moon, Chang Oh] Background: Morphological studies investigating the intracranial-extradural internal carotid artery with moyamoya disease have not been reported. We designed this case-control study to investigate the morphological differences of the internal carotid artery with moyamoya disease, and to clarify the contributions of these differences to the resultant fluid dynamics. Methods: Patients with moyamoya disease and normal controls were assigned to each group. The vascular tortuosity of internal carotid artery was measured with three-dimensional rendering using magnetic resonance angiography. By computational fluid dynamics, hemodynamic characteristics were simulated and compared between two groups. Results: Distances were measured from the carotid canal to the siphon. A shorter actual distance was observed in the moyamoya group (p = 0.0170). Vascular tortuosity was significantly low in moyamoya patients showing lower curvature angles in the petrous and intra-cavernous segments (p = 0.0012). Less blood flowed (p < 0.0001) through the narrower internal carotid artery (p < 0.0001) in the moyamoya group at the carotid canal level. The blood flow velocities were not significantly different (p = 0.2332). Faster blood flow and higher wall shear stress in the internal carotid artery bifurcation were verified with computational fluid dynamics. Conclusions: Significant morphological differences were confirmed to exist in the intracranial-extradural internal carotid artery of moyamoya patients. These differences might influence the hemodynamics around the bifurcation of the internal carotid artery. Springer-Verlag Wien, 2015 Hemodynamics nationallicence Moyamoya disease nationallicence Vascular morphology nationallicence Kim Tackeun Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut Bang Jae Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut Kwon O-Ki Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut Hwang Gyojun Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut Kim Jeong Department of Neurosurgery, Seoul National University Hospital, 101 Daehak-Ro, 110-744, Seoul, Jongno-Gu, Republic of Korea aut Kang Hyun-Seung Department of Neurosurgery, Seoul National University Hospital, 101 Daehak-Ro, 110-744, Seoul, Jongno-Gu, Republic of Korea aut Cho Won Department of Neurosurgery, Seoul National University Hospital, 101 Daehak-Ro, 110-744, Seoul, Jongno-Gu, Republic of Korea aut Moon Jong Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut Oh Chang Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut Acta Neurochirurgica Springer Vienna 157/5(2015-05-01), 755-761 0001-6268 157:5<755 2015 157 701 https://doi.org/10.1007/s00701-015-2367-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2367-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Tackeun Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Bang Jae Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Kwon O-Ki Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Hwang Gyojun Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Kim Jeong Department of Neurosurgery, Seoul National University Hospital, 101 Daehak-Ro, 110-744, Seoul, Jongno-Gu, Republic of Korea aut NATIONALLICENCE 700 1- Kang Hyun-Seung Department of Neurosurgery, Seoul National University Hospital, 101 Daehak-Ro, 110-744, Seoul, Jongno-Gu, Republic of Korea aut NATIONALLICENCE 700 1- Cho Won Department of Neurosurgery, Seoul National University Hospital, 101 Daehak-Ro, 110-744, Seoul, Jongno-Gu, Republic of Korea aut NATIONALLICENCE 700 1- Moon Jong Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Oh Chang Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/5(2015-05-01), 755-761 0001-6268 157:5<755 2015 157 701