caa a22 4500 606216227 CHVBK 20210128101102.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00701-015-2375-y doi (NATIONALLICENCE)springer-10.1007/s00701-015-2375-y Sporadic meningioangiomatosis with and without meningioma: analysis of clinical differences and risk factors for poor seizure outcomes [Elektronische Daten] [Chao Zhang, Yao Wang, Xiu Wang, Jian-Guo Zhang, Jing-Jun Li, Wen-Han Hu, Kai Zhang] Background: Meningioangiomatosis (MA) is a rare cerebral lesion. Sporadic MA occasionally combines with meningioma (MA-M). The aim of the present study was to clarify whether MA-M and pure MA have clinical differences and to determine risk factors for unsatisfactory seizure outcomes in sporadic MA. Methods: We reported 14 sporadic MA cases in our center and conducted a literature review. We compared the demographic, clinical, imaging, electrophysiological and pathological features and surgical outcomes. Logistic regression analysis was performed to evaluate the risk factors for poor seizure outcomes. Results: MA-M cases showed a more prominent male predilection (4.2 times vs. 1.6 times, p = 0.04), a shorter duration of symptoms (2.8 ± 0.8years vs. 5.2 ± 0.6years, p = 0.02), and a lower seizure incidence (53.6% vs. 89.3%, p < 0.001) as compared to pure MA. A gyriform alteration on imaging was exclusively associated with pure MA. The Ki-67 was higher in the meningioma component than in the MA component in MA-M (1.2 ± 0.3% vs. 6.1 ± 1.1%, p < 0.001). Lesions located in the temporal lobe predicted poor seizure outcomes (p = 0.02, OR = 4.4, 95% confidence interval, 1.24-15.89). Conclusion: Clinical differences may be caused by the different biological natures. MA-M seems to be a neoplastic lesion, while pure MA seems to be a non-neoplastic lesion. Long-term follow-up is required for MA-M. Because the coexistence of hippocampal sclerosis may explain the poor seizure outcomes of MA located in the temporal lobe, it is important to identify underlying hippocampal sclerosis and to perform complete resection. Springer-Verlag Wien, 2015 Meningioangiomatosis nationallicence Meningioma nationallicence Seizures nationallicence Gyriform nationallicence Zhang Chao Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, 100050, Beijing, China aut Wang Yao Beijing Jingmei Group General Hospital, 102300, Beijing, China aut Wang Xiu Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, 100050, Beijing, China aut Zhang Jian-Guo Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, 100050, Beijing, China aut Li Jing-Jun Department of Pathology, Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China aut Hu Wen-Han Stereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China aut Zhang Kai Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, 100050, Beijing, China aut Acta Neurochirurgica Springer Vienna 157/5(2015-05-01), 841-853 0001-6268 157:5<841 2015 157 701 https://doi.org/10.1007/s00701-015-2375-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2375-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Chao Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, 100050, Beijing, China aut NATIONALLICENCE 700 1- Wang Yao Beijing Jingmei Group General Hospital, 102300, Beijing, China aut NATIONALLICENCE 700 1- Wang Xiu Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, 100050, Beijing, China aut NATIONALLICENCE 700 1- Zhang Jian-Guo Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, 100050, Beijing, China aut NATIONALLICENCE 700 1- Li Jing-Jun Department of Pathology, Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China aut NATIONALLICENCE 700 1- Hu Wen-Han Stereotactic and Functional Neurosurgery Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 100050, Beijing, China aut NATIONALLICENCE 700 1- Zhang Kai Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, 100050, Beijing, China aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/5(2015-05-01), 841-853 0001-6268 157:5<841 2015 157 701