caa a22 4500 606216359 CHVBK 20210128101103.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00701-015-2366-z doi (NATIONALLICENCE)springer-10.1007/s00701-015-2366-z Tumor burden evaluation in NF1 patients with plexiform neurofibromas in daily clinical practice [Elektronische Daten] [L. Pratt, D. Helfer, L. Weizman, B. Shofty, S. Constantini, L. Joskowicz, D. Ben Bashat, L. Ben-Sira] Background: Existing volumetric measurements of plexiform neurofibromas (PNs) are time consuming and error prone, as they require delineation of PN boundaries, a procedure that is not practical in the typical clinical setting. The aim of this study is to assess the Plexiform Neurofibroma Instant Segmentation Tool (PNist), a novel semi-automated segmentation program that we developed for PN delineation in a clinical context. PNist was designed to greatly simplify volumetric assessment of PNs through use of an intuitive user interface while providing objectively consistent results with minimal interobserver and intraobserver variabilities in reasonable time. Materials and methods: PNs were measured in 30 magnetic resonance imaging (MRI) scans from 12 patients with neurofibromatosis 1. Volumetric measurements were performed using PNist and compared to a standard semi-automated volumetric method (Analyze 9.0). Results: High correlation was detected between PNist and the semi-automated method (R 2 = 0.996), with a mean volume overlap error of 9.54% and low intraobserver and interobserver variabilities. The segmentation time required for PNist was 60% of the time required for Analyze 9.0 (360 versus 900s, respectively). PNist was also reliable when assessing changes in tumor size over time, compared to the existing commercial method. Conclusions: Our study suggests that the new PNist method is accurate, intuitive, and less time consuming for PN segmentation compared to existing commercial volumetric methods. The workflow is simple and user-friendly, making it an important clinical tool to be used by radiologists, neurologists and neurosurgeons on a daily basis, helping them deal with the complex task of evaluating PN burden and progression. Springer-Verlag Wien, 2015 Plexiform neurofibroma nationallicence Neurofibromatosis 1 nationallicence Tumor burden nationallicence Volumetry nationallicence Pratt L. Imaging Division, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel aut Helfer D. School of Engineering and Computer Science, The Hebrew University of Jerusalem, Jerusalem, Israel aut Weizman L. School of Engineering and Computer Science, The Hebrew University of Jerusalem, Jerusalem, Israel aut Shofty B. Department of Pediatric Neurosurgery, and the Gilbert International Neurofibromatosis Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel aut Constantini S. Department of Pediatric Neurosurgery, and the Gilbert International Neurofibromatosis Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel aut Joskowicz L. School of Engineering and Computer Science, The Hebrew University of Jerusalem, Jerusalem, Israel aut Ben Bashat D. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut Ben-Sira L. Imaging Division, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel aut Acta Neurochirurgica Springer Vienna 157/5(2015-05-01), 855-861 0001-6268 157:5<855 2015 157 701 https://doi.org/10.1007/s00701-015-2366-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2366-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pratt L. Imaging Division, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Helfer D. School of Engineering and Computer Science, The Hebrew University of Jerusalem, Jerusalem, Israel aut NATIONALLICENCE 700 1- Weizman L. School of Engineering and Computer Science, The Hebrew University of Jerusalem, Jerusalem, Israel aut NATIONALLICENCE 700 1- Shofty B. Department of Pediatric Neurosurgery, and the Gilbert International Neurofibromatosis Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Constantini S. Department of Pediatric Neurosurgery, and the Gilbert International Neurofibromatosis Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Joskowicz L. School of Engineering and Computer Science, The Hebrew University of Jerusalem, Jerusalem, Israel aut NATIONALLICENCE 700 1- Ben Bashat D. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Ben-Sira L. Imaging Division, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/5(2015-05-01), 855-861 0001-6268 157:5<855 2015 157 701