caa a22 4500 606216383 CHVBK 20210128101103.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00701-014-2309-0 doi (NATIONALLICENCE)springer-10.1007/s00701-014-2309-0 Persistent communicating hydrocephalus in adult tuberous sclerosis patients: a possible therapeutic role for everolimus [Elektronische Daten] [Yosef Laviv, Steven Jackson, Zvi Rappaport] Subependymal giant cell tumor (SGCT) is a benign intraventricular tumor, usually located near the foramen of Monro. It is almost always associated with tuberous sclerosis complex (TSC). SGCTs may obstruct cerebrospinal fluid (CSF) pathways. Rarely, they may secrete a protein-rich exudate, causing communicating hydrocephalus. Surgery is indicated for symptomatic lesions or growing asymptomatic lesions. The operative approach to SGCT has shifted from simple shunt placement to a more aggressive approach, leading to early attempts at gross total resection. Recently, the mTOR inhibitor everolimus has been approved for treating SGCT. In this article, we present two cases of recurrent shunt malfunctions in adult TSC patients with protein-secreting SGCTs. We describe the complexity of treating such patients with an emphasis on the role mTOR inhibitors may have in their management. We also review the literature on surgical management of SGCT-related hydrocephalus. Springer-Verlag Wien, 2014 Tuberous sclerosis nationallicence Hydrocephalus nationallicence Subependymal giant cell tumor nationallicence Everolimus nationallicence Laviv Yosef Beilinson hospital, Rabin Medical Center, Neurosurgery Rabin Medical Center City, 49100, Petah Tiqva, Israel aut Jackson Steven Beilinson hospital, Rabin Medical Center, Neurosurgery Rabin Medical Center City, 49100, Petah Tiqva, Israel aut Rappaport Zvi Beilinson hospital, Rabin Medical Center, Neurosurgery Rabin Medical Center City, 49100, Petah Tiqva, Israel aut Acta Neurochirurgica Springer Vienna 157/2(2015-02-01), 241-245 0001-6268 157:2<241 2015 157 701 https://doi.org/10.1007/s00701-014-2309-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-014-2309-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Laviv Yosef Beilinson hospital, Rabin Medical Center, Neurosurgery Rabin Medical Center City, 49100, Petah Tiqva, Israel aut NATIONALLICENCE 700 1- Jackson Steven Beilinson hospital, Rabin Medical Center, Neurosurgery Rabin Medical Center City, 49100, Petah Tiqva, Israel aut NATIONALLICENCE 700 1- Rappaport Zvi Beilinson hospital, Rabin Medical Center, Neurosurgery Rabin Medical Center City, 49100, Petah Tiqva, Israel aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/2(2015-02-01), 241-245 0001-6268 157:2<241 2015 157 701