caa a22 4500 606216510 CHVBK 20210128101103.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00701-014-2271-x doi (NATIONALLICENCE)springer-10.1007/s00701-014-2271-x Anatomic features of glioblastoma and their potential impact on survival [Elektronische Daten] [U. Nestler, K. Lutz, U. Pichlmeier, W. Stummer, K. Franz, H-J Reulen, A. Bink] Background: Many reports on glioblastoma multiforme discuss the prognostic impact of anatomical features such as cysts, necrotic changes, extent of edema or subependymal spread of tumor cells. In the present study, we examined different growth patterns and their possible relations to patient survival. Methods: To analyze whether anatomical characteristics are related to prognosis, we reviewed the prospectively collected pre- and postoperative MRIs of 83 patients in the 5-ALA study, provided by the 5-ALA Glioma Study Group. Following a standardized analytic work flow, the tumor volume and site, presence of necrosis or cysts, and perifocal edema were assessed preoperatively. In the same way, postoperative MRI and the MRI at first recurrence were analyzed. In addition, survival time of the patients was documented. Results: Median survival time of all 83 patients was 15.1months (range 1.5 to 70.1, mean 18). The site or volume of glioblastoma, as well as the presence of intratumoral necrosis or cysts, did not exert a significant effect on survival time; 96.4% of recurrences occurred within the former resection margin. Tumors with initial contact with the subependymal zone had multifocal or ventricular recurrences significantly more often. In patients with residual tumor on early postoperative MRI, the follow-up images displayed enlargement of the remnants in 91.9% of these cases. Conclusions: A merely anatomical analysis of the glioblastoma growth pattern cannot reliably provide prognostic information. The occurrence of most recurrences next to the resection margin and the high percentage of growing residual tumors underline the importance of complete resections. Springer-Verlag Wien, 2014 5-ALA Study Group nationallicence Cyst nationallicence Glioblastoma nationallicence Necrosis nationallicence Prognosis nationallicence ctx+ : Tumor tissue is present in the cerebral cortex nationallicence ctx- : Tumor tissue is absent in the cerebral cortex nationallicence GBM : Glioblastoma multiforme nationallicence n.a. : Not applicable nationallicence n.r. : Not reported nationallicence svz+ : Tumor tissue is present in the subventricular zone nationallicence svz- : Tumor tissue is absent in the subventricular zone nationallicence T2w-HSC : T2-weighted hyperintense signal change nationallicence p.s. : Present study nationallicence Parts of this article were published as an oral presentation at the meeting of the Neurooncologic Group of the German Society of Neurosurgery (Jahrestagung der Sektion Neuroonkologie der DGNC) : Bonn 2009 nationallicence Nestler U. Department of Neurosurgery, Justus Liebig University, Giessen, Germany aut Lutz K. Department of Neurosurgery, Justus Liebig University, Giessen, Germany aut Pichlmeier U. medac GmbH, Wedel, Germany aut Stummer W. Department of Neurosurgery, University Clinic, Münster, Germany aut Franz K. Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany aut Reulen H-J Department of Neurosurgery, Ludwig Maximilian University, Munich, Germany aut Bink A. Department of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt, Germany aut Acta Neurochirurgica Springer Vienna 157/2(2015-02-01), 179-186 0001-6268 157:2<179 2015 157 701 https://doi.org/10.1007/s00701-014-2271-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-014-2271-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nestler U. Department of Neurosurgery, Justus Liebig University, Giessen, Germany aut NATIONALLICENCE 700 1- Lutz K. Department of Neurosurgery, Justus Liebig University, Giessen, Germany aut NATIONALLICENCE 700 1- Pichlmeier U. medac GmbH, Wedel, Germany aut NATIONALLICENCE 700 1- Stummer W. Department of Neurosurgery, University Clinic, Münster, Germany aut NATIONALLICENCE 700 1- Franz K. Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany aut NATIONALLICENCE 700 1- Reulen H-J Department of Neurosurgery, Ludwig Maximilian University, Munich, Germany aut NATIONALLICENCE 700 1- Bink A. Department of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt, Germany aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/2(2015-02-01), 179-186 0001-6268 157:2<179 2015 157 701