caa a22 4500 606216782 CHVBK 20210128101105.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00701-015-2587-1 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2587-1 Interobserver variability in the characterization of giant intracranial aneurysms with special emphasis on aneurysm diameter and shape [Elektronische Daten] [Maria Wostrack, Dorothee Mielke, Naoki Kato, Susanne Guhl, Nils Schmidt, Nicolai Maldaner, Peter Vajkoczy, Julius Dengler] Background: The Giant Intracranial Aneurysm Registry is a multicenter observational trial exclusively focusing on giant intracranial aneurysms (GIA). As no data exist on the interobserver variability in the radiological description of GIA, there is some uncertainty concerning the reliability of the GIA characteristics included in the registry. We have therefore designed a study to test the interobserver variability in the description of the specific GIA characteristics that are examined in the GIA registry. Methods: Six different raters analyzed imaging of five GIA concerning GIA location, GIA size, GIA shape, GIA thrombosis, and the presence of perianeurysmal edema. Interobserver variability was examined using intraclass correlation and Fleiss' kappa analysis. Results: The intraclass correlation coefficient was 0.99 (95% CI 0.97-1.0) for the largest GIA diameter and 0.98 (95% CI 0.94-1.0) for the largest GIA diameter in an axial imaging slice. We found perfect interobserver agreement (Fleiss' kappa 1.00) in the characterization of GIA location and the presence of perianeurysmal edema and almost perfect interobserver agreement for GIA thrombosis (Fleiss' kappa 0.86, 95% CI 0.63-1.00). Only moderate interobserver agreement was found in the description of GIA shape (Fleiss' kappa 0.50, 95% CI 0.27-0.73). Conclusions: While GIA size, location, thrombosis, and the presence of perianeurysmal edema showed excellent interobserver agreement, the description of GIA shape was achieved with only moderate agreement. Data on GIA shape in multicenter studies, like the GIA registry, should therefore be discussed with caution and potentially reassessed in a centralized fashion. Springer-Verlag Wien, 2015 Giant intracranial aneurysm nationallicence Interobserver variability nationallicence Partially thrombosed intracranial aneurysm nationallicence Neurovascular imaging nationallicence Wostrack Maria Department of Neurosurgery, Technical University of Munich, Munich, Germany aut Mielke Dorothee Department of Neurosurgery, Georg-August-University Goettingen, Göttingen, Germany aut Kato Naoki Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan aut Guhl Susanne Department of Neurosurgery, University of Greifswald, Greifswald, Germany aut Schmidt Nils Department of Neurosurgery, University Medical Center, Hamburg Eppendorf, Germany aut Maldaner Nicolai Department of Neurosurgery, Charité - Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany aut Vajkoczy Peter Department of Neurosurgery, Charité - Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany aut Dengler Julius Department of Neurosurgery, Charité - Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany aut Acta Neurochirurgica Springer Vienna 157/11(2015-11-01), 1859-1865 0001-6268 157:11<1859 2015 157 701 https://doi.org/10.1007/s00701-015-2587-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2587-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wostrack Maria Department of Neurosurgery, Technical University of Munich, Munich, Germany aut NATIONALLICENCE 700 1- Mielke Dorothee Department of Neurosurgery, Georg-August-University Goettingen, Göttingen, Germany aut NATIONALLICENCE 700 1- Kato Naoki Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Guhl Susanne Department of Neurosurgery, University of Greifswald, Greifswald, Germany aut NATIONALLICENCE 700 1- Schmidt Nils Department of Neurosurgery, University Medical Center, Hamburg Eppendorf, Germany aut NATIONALLICENCE 700 1- Maldaner Nicolai Department of Neurosurgery, Charité - Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 700 1- Vajkoczy Peter Department of Neurosurgery, Charité - Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 700 1- Dengler Julius Department of Neurosurgery, Charité - Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/11(2015-11-01), 1859-1865 0001-6268 157:11<1859 2015 157 701