caa a22 4500 60621691X CHVBK 20210128101105.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00701-015-2578-2 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2578-2 Seizure outcomes in relation to the extent of resection of the perifocal fluorodeoxyglucose and flumazenil PET abnormalities in anteromedial temporal lobectomy [Elektronische Daten] [Milo Stanišić, Christopher Coello, Jugoslav Ivanović, Arild Egge, Torsten Danfors, John Hald, Einar Heminghyt, Marjan Mikkelsen, Bård Krossnes, Are Pripp, Pål Larsson] Background: The area of predominant perifocal [18F]fluorodeoxyglucose (18F-FDG) hypometabolism and reduced [11C]flumazenil (11C-FMZ) -binding on PET scans is currently considered to contain the epileptogenic zone and corresponds anatomically to the area localizing epileptogenicity in patients with temporal lobe epilepsy (TLE). The question is whether the volume of the perifocal pre-operative PET abnormalities, the extent of their resection, and the volume of the non-resected abnormalities affects the post-operative seizure outcome. Methods: The sample group consisted of 32 patients with mesial temporal sclerosis who underwent anteromedial temporal lobe resection for refractory TLE. All patients had pathologic perifocal findings on both of the PET modalities as well as on the whole-brain MRI. The volumetric data of the PET and MRI abnormalities within the resected temporal lobe were estimated by automated quantitative voxel-based analysis. The obtained volumetric data were investigated in relation to the outcome subgroups of patients (Engel classification) determined at the 2-year post-operative follow-up. Results: The mean volume of the pre-operative perifocal 18F-FDG- and 11C-FMZ PET abnormalities in the volumes of interest (VOI) of the epileptogenic temporal lobe, the mean resected volume of these PET abnormalities, the mean volume of the non-resected PET abnormalities, and the mean MRI-derived resected volume were not significantly related to the outcome subgroups and had a low prediction for individual freedom from seizures. Conclusions: The extent of pre-surgical perifocal PET abnormalities, the extent of their resection, and the extent of non-resected abnormalities were not useful predictors of individual freedom from seizures in patients with TLE. The Author(s), 2015 Temporal lobe epilepsy nationallicence 18F-FDG-PET nationallicence 11C-FMZ-PET nationallicence Post-operative outcome nationallicence Stanišić Milo Department of Neurosurgery Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway aut Coello Christopher PET Core Facility/PET Centre, Oslo University Hospital, Oslo, Norway aut Ivanović Jugoslav Department of Neurosurgery Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway aut Egge Arild Department of Neurosurgery Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway aut Danfors Torsten Section of Nuclear Medicine & PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden aut Hald John Department of Radiology, Oslo University Hospital, Oslo, Norway aut Heminghyt Einar Department of Clinical Psychology and Neuropsychology, National Center for Epilepsy, Oslo University Hospital, Oslo, Norway aut Mikkelsen Marjan Department of Adult Epilepsy, National Center for Epilepsy, Oslo University Hospital, Oslo, Norway aut Krossnes Bård Department of Pathology, Oslo University Hospital, Oslo, Norway aut Pripp Are Oslo Center of Biostatistics and Epidemiology, Research Support Service, Oslo University Hospital, Oslo, Norway aut Larsson Pål Clinical Neurophysiologic Laboratories, Department of Neurosurgery, Oslo University Hospital, Oslo, Norway aut Acta Neurochirurgica Springer Vienna 157/11(2015-11-01), 1905-1916 0001-6268 157:11<1905 2015 157 701 https://doi.org/10.1007/s00701-015-2578-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2578-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stanišić Milo Department of Neurosurgery Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway aut NATIONALLICENCE 700 1- Coello Christopher PET Core Facility/PET Centre, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Ivanović Jugoslav Department of Neurosurgery Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway aut NATIONALLICENCE 700 1- Egge Arild Department of Neurosurgery Rikshospitalet, Oslo University Hospital, Sognsvannsveien 20, 0027, Oslo, Norway aut NATIONALLICENCE 700 1- Danfors Torsten Section of Nuclear Medicine & PET, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden aut NATIONALLICENCE 700 1- Hald John Department of Radiology, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Heminghyt Einar Department of Clinical Psychology and Neuropsychology, National Center for Epilepsy, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Mikkelsen Marjan Department of Adult Epilepsy, National Center for Epilepsy, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Krossnes Bård Department of Pathology, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Pripp Are Oslo Center of Biostatistics and Epidemiology, Research Support Service, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Larsson Pål Clinical Neurophysiologic Laboratories, Department of Neurosurgery, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/11(2015-11-01), 1905-1916 0001-6268 157:11<1905 2015 157 701