caa a22 4500 606216960 CHVBK 20210128101105.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00701-015-2555-9 doi (NATIONALLICENCE)springer-10.1007/s00701-015-2555-9 Statistical shape analysis of temporal lobe in mesial temporal sclerosis patients [Elektronische Daten] [Gokhan Ocakoglu, M. Taskapilioglu, Ilker Ercan, Aylin Demir, Bahattin Hakyemez, Ahmet Bekar, Ibrahim Bora] Background: Surgery is regarded as a common treatment option for patients with mesial temporal lobe epilepsy due to hippocampal sclerosis but sometimes deciding this diagnosis can be very difficult. We aim to investigate the shape differences in the temporal lobe of mesial temporal sclerosis epilepsy patients compared with healthy controls, investigating the side difference and, if present, assessing the clinical application of this situation. Method: The MRI scans of mesial TLE patients and controls were retrospectively reviewed. Temporal lobe data were collected from the two-dimensional digital images. Standard anthropometric landmarks were selected and marked on each digital image using TPSDIG 2.04 software. Eight anatomic landmarks were marked on images. A generalized Procrustes analysis was used to evaluate the shape difference. The shape deformation of the temporal lobe from control to patient was evaluated using the TPS method. Results: There were statistically significant TL shape differences between groups. High level deformations for the left and right side from the control to patient group were seen in the TPS graphic. The highest deformation was determined at the inferior lateral temporal midpoint of the middle temporal gyri and superior temporal landmark points of both the right and left sides. Conclusion: Our study for the first time demonstrated temporal shape differences in TLE patients using a landmark-based geometrical morphometric method by taking into consideration the topographic distribution of TL. Springer-Verlag Wien, 2015 Mesial temporal lobe nationallicence Hippocampal sclerosis nationallicence Epilepsy nationallicence Statistical shape analysis nationallicence Ocakoglu Gokhan Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey aut Taskapilioglu M. Department of Neurosurgery, Faculty of Medicine, Uludag University, Bursa, Turkey aut Ercan Ilker Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey aut Demir Aylin Department of Neurology, Faculty of Medicine, Uludag University, Bursa, Turkey aut Hakyemez Bahattin Department of Radiology, Faculty of Medicine, Uludag University, Bursa, Turkey aut Bekar Ahmet Department of Neurosurgery, Faculty of Medicine, Uludag University, Bursa, Turkey aut Bora Ibrahim Department of Neurology, Faculty of Medicine, Uludag University, Bursa, Turkey aut Acta Neurochirurgica Springer Vienna 157/11(2015-11-01), 1897-1903 0001-6268 157:11<1897 2015 157 701 https://doi.org/10.1007/s00701-015-2555-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00701-015-2555-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ocakoglu Gokhan Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey aut NATIONALLICENCE 700 1- Taskapilioglu M. Department of Neurosurgery, Faculty of Medicine, Uludag University, Bursa, Turkey aut NATIONALLICENCE 700 1- Ercan Ilker Department of Biostatistics, Faculty of Medicine, Uludag University, Bursa, Turkey aut NATIONALLICENCE 700 1- Demir Aylin Department of Neurology, Faculty of Medicine, Uludag University, Bursa, Turkey aut NATIONALLICENCE 700 1- Hakyemez Bahattin Department of Radiology, Faculty of Medicine, Uludag University, Bursa, Turkey aut NATIONALLICENCE 700 1- Bekar Ahmet Department of Neurosurgery, Faculty of Medicine, Uludag University, Bursa, Turkey aut NATIONALLICENCE 700 1- Bora Ibrahim Department of Neurology, Faculty of Medicine, Uludag University, Bursa, Turkey aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer Vienna 157/11(2015-11-01), 1897-1903 0001-6268 157:11<1897 2015 157 701