caa a22 4500 606220526 CHVBK 20210128101124.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00380-013-0442-y doi (NATIONALLICENCE)springer-10.1007/s00380-013-0442-y Association of atherosclerosis-related markers and its relationship to n-3 polyunsaturated fatty acids levels with a prevalence of coronary artery disease in an urban area in Japan [Elektronische Daten] [Shigemasa Tani, Ken Nagao, Atsushi Hirayama] Higher intakes of fish and n-3 polyunsaturated fatty acids (n-3PUFAs: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) are associated with a reduced risk of coronary artery disease (CAD). We investigated the relationships between fish-derived n-3PUFAs and prevalence of CAD, and to assess the association of n-3PUFAs with atherosclerosis-related markers in an urban area. This study was designed as a hospital-based cross-sectional study on 649 consecutive outpatients who had undergone regular examinations between April 2009 and October 2009. After adjustments for the coronary risk factors in a multilogistic regression analysis of variables for which a significant difference was identified between the group of patients with a prevalence of CAD and the group with no prevalence of CAD, the multivariable odds ratio (95 % confidence interval) was 0.394 (0.205/0.760; P = 0.005) for the highest (92.4-373.5 μg/ml) versus lowest (6.2-40.0 μg/ml) quartile of serum EPA values and 0.433 (0.228/0.824; P = 0.011) for the highest (160.7-451.8 μg/ml) versus lowest (35.7-100.7 μg/ml) quartile of serum DHA values. Multivariate regression analyses after adjustment for risk factors showed that higher serum EPA and DHA levels were independent variables of a higher level of serum apolipoprotein A-1, a major compound of high-density lipoprotein. However, the results suggested that there might be conflicting effects of EPA and DHA in regard of the serum levels of other lipid markers. This cross-sectional study suggests that higher serum levels of n-3PUFAs were associated with a lower prevalence of CAD and an increase in serum apolipoprotein A-1 level, even in an urban area. Springer Japan, 2013 Apolipoprotein A-1 nationallicence Coronary artery disease nationallicence High-density lipoprotein cholesterol nationallicence n-3 Polyunsaturated fatty acid nationallicence Tani Shigemasa Department of Cardiology, Surugadai Nihon University Hospital, 1-8-13 Kanda-Surugadai, Chiyoda-ku, 101-8309, Tokyo, Japan aut Nagao Ken Department of Cardiology, Surugadai Nihon University Hospital, 1-8-13 Kanda-Surugadai, Chiyoda-ku, 101-8309, Tokyo, Japan aut Hirayama Atsushi Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut Heart and Vessels Springer Japan 30/1(2015-01-01), 9-19 0910-8327 30:1<9 2015 30 380 https://doi.org/10.1007/s00380-013-0442-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-013-0442-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tani Shigemasa Department of Cardiology, Surugadai Nihon University Hospital, 1-8-13 Kanda-Surugadai, Chiyoda-ku, 101-8309, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagao Ken Department of Cardiology, Surugadai Nihon University Hospital, 1-8-13 Kanda-Surugadai, Chiyoda-ku, 101-8309, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirayama Atsushi Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/1(2015-01-01), 9-19 0910-8327 30:1<9 2015 30 380