caa a22 4500 606220534 CHVBK 20210128101124.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00380-013-0458-3 doi (NATIONALLICENCE)springer-10.1007/s00380-013-0458-3 Fasudil improves short-term echocardiographic parameters of diastolic function in patients with type 2 diabetes with preserved left ventricular ejection fraction: a pilot study [Elektronische Daten] [Rong Guo, Yang Su, Jing Yan, Hui Sun, Jiakang Wu, Weijing Liu, Yawei Xu] Left ventricular (LV) diastolic dysfunction is observed frequently in patients with type 2 diabetes; however, few studies have focused on the effect of the Rho-associated kinase inhibitor fasudil on cardiac performance in humans. We conducted a prospective pilot study to assess the impact of fasudil on LV diastolic function in patients with diabetes without systolic dysfunction. Two hundred and fifty eligible patients with type 2 diabetes (149 men [61.3%] and 94 women [38.7%]) with a mean age of 57.2years were randomly assigned to fasudil (n=122, 30mg intravenously twice a day for 14days) or placebo (n=121) groups. Echocardiographic variables were measured at the baseline and 1 month after the intervention. Compared with the placebo group, the fasudil group showed a significant decrease in diastolic blood pressure and in the peak of late diastolic transmitral flow (Am) (P<0.05 for both). Deceleration time (DT), isovolumic relaxation time (IVRT), the peak of early diastolic annular velocity (e′), the peak of late diastolic annular velocity, and E/e′ also exhibited a significant improvement (all, P<0.05) after fasudil administration. Furthermore, the Em/Am ratio and IVRT, DT, and E/e′ values recorded after fasudil treatment in the subgroup with impaired LV relaxation significantly differed from the corresponding values in the subgroup with normal LV relaxation (all, P<0.05). Fasudil improves short-term echocardiographic parameters of LV diastolic function in patients with type 2 diabetes with preserved left ventricular ejection fraction. Springer Japan, 2014 Rho-kinase inhibitor nationallicence Fasudil nationallicence Diastolic dysfunction nationallicence Type 2 diabetes nationallicence Guo Rong Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut Su Yang Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut Yan Jing Department of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut Sun Hui Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut Wu Jiakang Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut Liu Weijing Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut Xu Yawei Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut Heart and Vessels Springer Japan 30/1(2015-01-01), 89-97 0910-8327 30:1<89 2015 30 380 https://doi.org/10.1007/s00380-013-0458-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-013-0458-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guo Rong Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut NATIONALLICENCE 700 1- Su Yang Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut NATIONALLICENCE 700 1- Yan Jing Department of Endocrinology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut NATIONALLICENCE 700 1- Sun Hui Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut NATIONALLICENCE 700 1- Wu Jiakang Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut NATIONALLICENCE 700 1- Liu Weijing Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut NATIONALLICENCE 700 1- Xu Yawei Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yan Chang Zhong Road, 200072, Shanghai, China aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/1(2015-01-01), 89-97 0910-8327 30:1<89 2015 30 380