caa a22 4500 606220550 CHVBK 20210128101124.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00380-013-0453-8 doi (NATIONALLICENCE)springer-10.1007/s00380-013-0453-8 Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound [Elektronische Daten] [Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita] Thin-cap fibroatheroma (TCFA) is the most common type of vulnerable plaque and is the precursor of plaque rupture. However, rupture of a TCFA is not the only mechanism underlying thrombus formation or acute coronary syndrome. Although statin therapy changes the composition of coronary artery plaques, the effects of statins, particularly different types of statins, on plaque phenotype have not been fully examined. This study compared the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by virtual histology (VH) intravascular ultrasound (IVUS) in patients with angina pectoris (AP). Coronary atherosclerosis in nonculprit lesions was evaluated using VH-IVUS at baseline and 8 months after statin therapy; analyzable IVUS data were obtained from 83 patients with stable AP (39 patients treated with pitavastatin and 44 with pravastatin) and 36 patients with unstable AP (19 patients treated with pitavastatin and 17 with pravastatin). Pitavastatin had a strong effect on reducing pathologic intimal thickening (PIT), especially in patients with unstable AP, but had no impact on VH-TCFA or fibroatheroma (FA). By contrast, pravastatin had weak effects on reducing PIT, VH-TCFA, or FA. Increases in the number of calcified plaques were observed for both statins. In conclusion, pitavastatin and pravastatin changed coronary artery plaque phenotype as assessed by VH-IVUS in patients with AP. However, the effects of these statins on coronary artery plaque phenotype were different. Springer Japan, 2013 Plaque phenotype nationallicence Statin nationallicence Thin-cap fibroatheroma nationallicence Virtual histology intravascular ultrasound nationallicence Nozue Tsuyoshi Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan aut Yamamoto Shingo Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan aut Tohyama Shinichi Department of Cardiology, Yokohama Seamen's Insurance Hospital, Yokohama, Japan aut Fukui Kazuki Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan aut Umezawa Shigeo Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan aut Onishi Yuko Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan aut Kunishima Tomoyuki Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan aut Sato Akira Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan aut Nozato Toshihiro Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan aut Miyake Shogo Department of Cardiology, Ebina General Hospital, Ebina, Japan aut Takeyama Youichi Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan aut Morino Yoshihiro Department of Cardiology, Tokai University School of Medicine, Isehara, Japan aut Yamauchi Takao Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan aut Muramatsu Toshiya Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan aut Hibi Kiyoshi Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan aut Terashima Mitsuyasu Cardiovascular Imaging Center, Toyohashi, Japan aut Michishita Ichiro Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan aut Heart and Vessels Springer Japan 30/1(2015-01-01), 36-44 0910-8327 30:1<36 2015 30 380 https://doi.org/10.1007/s00380-013-0453-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-013-0453-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nozue Tsuyoshi Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan aut NATIONALLICENCE 700 1- Yamamoto Shingo Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan aut NATIONALLICENCE 700 1- Tohyama Shinichi Department of Cardiology, Yokohama Seamen's Insurance Hospital, Yokohama, Japan aut NATIONALLICENCE 700 1- Fukui Kazuki Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan aut NATIONALLICENCE 700 1- Umezawa Shigeo Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan aut NATIONALLICENCE 700 1- Onishi Yuko Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan aut NATIONALLICENCE 700 1- Kunishima Tomoyuki Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan aut NATIONALLICENCE 700 1- Sato Akira Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan aut NATIONALLICENCE 700 1- Nozato Toshihiro Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan aut NATIONALLICENCE 700 1- Miyake Shogo Department of Cardiology, Ebina General Hospital, Ebina, Japan aut NATIONALLICENCE 700 1- Takeyama Youichi Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan aut NATIONALLICENCE 700 1- Morino Yoshihiro Department of Cardiology, Tokai University School of Medicine, Isehara, Japan aut NATIONALLICENCE 700 1- Yamauchi Takao Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Muramatsu Toshiya Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan aut NATIONALLICENCE 700 1- Hibi Kiyoshi Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan aut NATIONALLICENCE 700 1- Terashima Mitsuyasu Cardiovascular Imaging Center, Toyohashi, Japan aut NATIONALLICENCE 700 1- Michishita Ichiro Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/1(2015-01-01), 36-44 0910-8327 30:1<36 2015 30 380