caa a22 4500 606220569 CHVBK 20210128101124.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00380-013-0462-7 doi (NATIONALLICENCE)springer-10.1007/s00380-013-0462-7 Effect of the Kv1.3 voltage-gated potassium channel blocker PAP-1 on the initiation and progress of atherosclerosis in a rat model [Elektronische Daten] [Xiaofen Wu, Rende Xu, Ming Cao, Lei Ruan, Xingfen Wang, Cuntai Zhang] Acute coronary syndrome is a serious medical emergency. It occurs when an atherosclerotic plaque ruptures, leading to thrombus formation within a coronary artery. Previous studies have shown that T cells are involved in the initiation and progression of acute coronary syndrome. CD4+CD28null T lymphocytes increase in atherosclerotic plaque, and voltage-gated potassium channel Kv1.3 blockers can suppress the function of these cells in vitro by preventing exocytosis of their cytoplasmic granules. The purpose of this study was to investigate the effect of PAP-1, a small molecule voltage-gated potassium channel Kv1.3 blocker, on the development of atherosclerosis (AS) in a rat model and the potential mechanism for this effect. Plasma lipids, interferonγ, CRP, CD4+CD28null T cells, and perforin were increased and unstable atherosclerotic plaques developed in the rat model of AS. Blockade of the Kv1.3 potassium channel via PAP-1 administration decreased perforin levels and prevented plaque formation but had no effect on the other changes seen in this AS model. These findings suggest that the small molecule, voltage-gated potassium channel Kv1.3 blocker PAP-1 can suppress the development of AS in a rat model, most likely by inhibiting the exocytosis of cytoplasmic granules from CD4+CD28null T cells. Springer Japan, 2014 Atherosclerosis plaque nationallicence T lymphocyte nationallicence Kv1.3 potassium channel nationallicence Wu Xiaofen Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut Xu Rende Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut Cao Ming Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut Ruan Lei Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut Wang Xingfen Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut Zhang Cuntai Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut Heart and Vessels Springer Japan 30/1(2015-01-01), 108-114 0910-8327 30:1<108 2015 30 380 https://doi.org/10.1007/s00380-013-0462-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-013-0462-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Xiaofen Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Xu Rende Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Cao Ming Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Ruan Lei Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Wang Xingfen Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Zhang Cuntai Department of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/1(2015-01-01), 108-114 0910-8327 30:1<108 2015 30 380