caa a22 4500 606220577 CHVBK 20210128101124.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00380-013-0449-4 doi (NATIONALLICENCE)springer-10.1007/s00380-013-0449-4 Platelet-larger cell ratio and the risk of periprocedural myocardial infarction after percutaneous coronary revascularization [Elektronische Daten] [Monica Verdoia, Lucia Barbieri, Alon Schaffer, Ettore Cassetti, Paolo Marino, Giorgio Bellomo, Fabiola Sinigaglia, Giuseppe De Luca] Periprocedural myocardial infarction (PMI) represents a frequent complication in patients undergoing percutaneous coronary revascularization. Despite great attention focused on pharmacological prevention of periprocedural damage, very little is known about using biomarkers to potentially predict the risk of PMI. Larger platelets have been associated with enhanced reactivity, increased cardiovascular risk, and higher rates of complications after coronary stenting. The platelet-larger cell ratio (P-LCR) identifies the largest-sized fraction of platelets, the proportion potentially more closely related to thrombotic events. The present study evaluated the relationship between P-LCR and PMI. We included 1,285 patients undergoing PCI. Myonecrosis biomarkers were dosed at intervals from 6 to 48 h after PCI. Periprocedural myonecrosis was defined as troponin I increase by three times the upper limit of normal (ULN) or by 50 % of an elevated baseline value, whereas PMI was defined as an increase in creatine kinase MB by 3 × ULN or 50 % of baseline. We grouped patients according to tertile values of P-LCR (<27.5; ≥35.1). Higher P-LCR was associated with age (P = 0.01), diabetes (P = 0.001), previous cerebrovascular accidents (P = 0.007), therapy with statins (P < 0.001), angiotensin receptor blockers (P < 0.001), aspirin (P = 0.002), and nitrates (P = 0.01). P-LCR was related to hemoglobin levels (P < 0.001), and inversely related to platelet count (P < 0.001) and glycemia (P = 0.05). Patients with higher P-LCR had a lower presence of coronary thrombus (P = 0.003). Higher P-LCR values did not increase the risk of PMI (P = 0.10; adjusted odds ratio (OR) (95 % confidence interval (CI)) = 0.97 (0.69-1.38)), P = 0.89) or periprocedural myonecrosis (P = 0.96; adjusted OR (95 % CI) = 1.003 (0.76-1.32), P = 0.99). Results were confirmed even in higher-risk subgroups of patients. P-LCR does not increase the risk of periprocedural myocardial infarction and myonecrosis in patients undergoing coronary stenting. Springer Japan, 2013 Platelets nationallicence Platelet-larger cell ratio nationallicence Percutaneous coronary intervention nationallicence Periprocedural myocardial infarction nationallicence Verdoia Monica Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut Barbieri Lucia Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut Schaffer Alon Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut Cassetti Ettore Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut Marino Paolo Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut Bellomo Giorgio Division of Clinical Chemistry, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, Novara, Italy aut Sinigaglia Fabiola Department of Translational Medicine, Centro di Biotecnologie per la Ricerca Medica Applicata (BRMA), Eastern Piedmont University, Novara, Italy aut De Luca Giuseppe Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut Heart and Vessels Springer Japan 30/1(2015-01-01), 20-27 0910-8327 30:1<20 2015 30 380 https://doi.org/10.1007/s00380-013-0449-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-013-0449-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Verdoia Monica Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 700 1- Barbieri Lucia Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 700 1- Schaffer Alon Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 700 1- Cassetti Ettore Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 700 1- Marino Paolo Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 700 1- Bellomo Giorgio Division of Clinical Chemistry, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, Novara, Italy aut NATIONALLICENCE 700 1- Sinigaglia Fabiola Department of Translational Medicine, Centro di Biotecnologie per la Ricerca Medica Applicata (BRMA), Eastern Piedmont University, Novara, Italy aut NATIONALLICENCE 700 1- De Luca Giuseppe Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità”, Eastern Piedmont University, C.so Mazzini 18, 28100, Novara, Italy aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/1(2015-01-01), 20-27 0910-8327 30:1<20 2015 30 380