caa a22 4500 60622064X CHVBK 20210128101124.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00380-014-0539-y doi (NATIONALLICENCE)springer-10.1007/s00380-014-0539-y Characteristics and clinical relevance of late gadolinium enhancement in cardiac magnetic resonance in patients with systemic sclerosis [Elektronische Daten] [Makoto Sano, Hiroshi Satoh, Kenichiro Suwa, Mamoru Nobuhara, Takeji Saitoh, Masao Saotome, Tsuyoshi Urushida, Hideki Katoh, Kumiko Shimoyama, Daisuke Suzuki, Noriyoshi Ogawa, Yasuo Takehara, Harumi Sakahara, Hideharu Hayashi] Cardiac involvement in systemic sclerosis (SSc) is considerably frequent in autopsy, but the early identification is clinically difficult. Recent advantages in cardiac magnetic resonance (CMR) enabled to detect myocardial fibrotic scar as late gadolinium enhancement (LGE). We aimed to examine the prevalence and distribution of LGE in patients with SSc, and associate them with clinical features, electrocardiographic abnormalities and cardiac function. Forty patients with SSc (58±14years-old, 35 females, limited/diffuse 25/15, disease duration 106±113months) underwent serological tests, 12-lead electrocardiogram (ECG) and CMR. Seven patients (17.5%) showed LGE in 26 segments of left ventricle (LV). LGE distributed mainly in the basal to mid inter-ventricular septum and the right ventricular (RV) insertion points, but involved all the myocardial regions. More patients with LGE showed NYHA functional class II and more (71 vs. 21%, p<0.05), bundle branch blocks (57 vs. 6%, p<0.05), LV ejection fraction (LVEF)<50% (72 vs. 6%, p<0.01), LV asynergy (43 vs. 0%, p<0.01) and RVEF<40% (100 vs. 39%, p<0.01). There was no difference in disease duration, disease types, or prevalence of positive autoimmune antibodies or high serum NT-proBNP level (>125pg/ml). When cardiac involvement of SSc was defined as low LVEF, ECG abnormalities or high NT-proBNP, the sensitivity, specificity positive and negative predictive values of LGE were 36, 92, 71 and 72%, respectively. We could clarify the prevalence and distribution of LGE in Japanese patients with SSc. The presence of LGE was associated with cardiac symptom, conduction disturbance and impaired LV/RV contraction. The Author(s), 2014 Electrocardiography nationallicence Conduction disturbance nationallicence Cardiac function nationallicence Systemic scleroderma nationallicence Late gadolinium enhancement nationallicence Sano Makoto Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut Satoh Hiroshi Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut Suwa Kenichiro Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut Nobuhara Mamoru Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut Saitoh Takeji Department of Emergency Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan aut Saotome Masao Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut Urushida Tsuyoshi Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut Katoh Hideki Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut Shimoyama Kumiko Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan aut Suzuki Daisuke Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan aut Ogawa Noriyoshi Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan aut Takehara Yasuo Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan aut Sakahara Harumi Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan aut Hayashi Hideharu Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut Heart and Vessels Springer Japan 30/6(2015-11-01), 779-788 0910-8327 30:6<779 2015 30 380 https://doi.org/10.1007/s00380-014-0539-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0539-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sano Makoto Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Satoh Hiroshi Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Suwa Kenichiro Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Nobuhara Mamoru Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Saitoh Takeji Department of Emergency Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Saotome Masao Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Urushida Tsuyoshi Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Katoh Hideki Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Shimoyama Kumiko Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Suzuki Daisuke Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Ogawa Noriyoshi Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Takehara Yasuo Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Sakahara Harumi Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Hayashi Hideharu Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/6(2015-11-01), 779-788 0910-8327 30:6<779 2015 30 380