caa a22 4500 606220690 CHVBK 20210128101125.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00380-014-0549-9 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0549-9 The effects of weight gain after smoking cessation on atherogenic α1-antitrypsin-low-density lipoprotein [Elektronische Daten] [Maki Komiyama, Hiromichi Wada, Shuichi Ura, Hajime Yamakage, Noriko Satoh-Asahara, Sayaka Shimada, Masaharu Akao, Hiroshi Koyama, Koichi Kono, Akira Shimatsu, Yuko Takahashi, Koji Hasegawa] Although cardiovascular risks decrease after quitting smoking, body weight often increases in the early period after smoking cessation. We have previously reported that the serum level of the α1-antitrypsin-low-density lipoprotein complex (AT-LDL)—an oxidatively modified low-density lipoprotein that accelerates atherosclerosis—is high in current smokers, and that the level rapidly decreases after smoking cessation. However, the effects of weight gain after smoking cessation on this cardiovascular marker are unknown. In 183 outpatients (134 males, 49 females) who had successfully quit smoking, serum AT-LDL levels were measured using an enzyme-linked immunosorbent assay. For all persons who had successfully quit smoking, body mass index (BMI) significantly increased 12weeks after the first examination (p<0.01). Among patients with a BMI increase smaller than the median, a significant decrease (p<0.01) in serum AT-LDL values was found, but no significant changes in serum AT-LDL values were found in patients with a BMI increase greater than the median. The findings suggest that the decrease in serum AT-LDL levels after quitting smoking is influenced by weight gain after smoking cessation. The Author(s), 2014 Smoking cessation nationallicence Obesity nationallicence Oxiditive stresss nationallicence Atherosclerosis nationallicence Prevention nationallicence Komiyama Maki Department of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut Wada Hiromichi Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, 612-8555, Kyoto, Japan aut Ura Shuichi Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, 612-8555, Kyoto, Japan aut Yamakage Hajime Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut Satoh-Asahara Noriko Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut Shimada Sayaka Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, 612-8555, Kyoto, Japan aut Akao Masaharu Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut Koyama Hiroshi Department of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut Kono Koichi Department of Hygiene and Public Health, Osaka Medical College, Osaka, Japan aut Shimatsu Akira Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut Takahashi Yuko Health Care Center, Nara Women's University, Nara, Japan aut Hasegawa Koji Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, 612-8555, Kyoto, Japan aut Heart and Vessels Springer Japan 30/6(2015-11-01), 734-739 0910-8327 30:6<734 2015 30 380 https://doi.org/10.1007/s00380-014-0549-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0549-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Komiyama Maki Department of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut NATIONALLICENCE 700 1- Wada Hiromichi Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, 612-8555, Kyoto, Japan aut NATIONALLICENCE 700 1- Ura Shuichi Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, 612-8555, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamakage Hajime Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut NATIONALLICENCE 700 1- Satoh-Asahara Noriko Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut NATIONALLICENCE 700 1- Shimada Sayaka Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, 612-8555, Kyoto, Japan aut NATIONALLICENCE 700 1- Akao Masaharu Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut NATIONALLICENCE 700 1- Koyama Hiroshi Department of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut NATIONALLICENCE 700 1- Kono Koichi Department of Hygiene and Public Health, Osaka Medical College, Osaka, Japan aut NATIONALLICENCE 700 1- Shimatsu Akira Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan aut NATIONALLICENCE 700 1- Takahashi Yuko Health Care Center, Nara Women's University, Nara, Japan aut NATIONALLICENCE 700 1- Hasegawa Koji Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, 612-8555, Kyoto, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/6(2015-11-01), 734-739 0910-8327 30:6<734 2015 30 380