caa a22 4500 606220739 CHVBK 20210128101125.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00380-014-0542-3 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0542-3 Impact of thin-cap fibroatheroma on predicting deteriorated coronary flow during interventional procedures in acute as well as stable coronary syndromes: insights from optical coherence tomography analysis [Elektronische Daten] [Tadatsugu Gamou, Kenji Sakata, Takao Matsubara, Toshihiko Yasuda, Kenji Miwa, Masaru Inoue, Honin Kanaya, Tetsuo Konno, Kenshi Hayashi, Masaaki Kawashiri, Masakazu Yamagishi] The occurrence of deteriorated coronary flow associated with distal embolization during percutaneous coronary intervention results in impaired myocardial perfusion and worsens the clinical prognosis. This study aimed to examine the impact of optical coherence tomography (OCT)-determined coronary plaque morphology on the prediction of deteriorated coronary flow after stent implantation in acute as well as stable coronary syndromes (ACS and SAP, respectively). We studied 126 patients who underwent OCT during stenting for ACS (n=44) and SAP (n=82) with a de novo lesion. Angiographic deteriorated coronary flow was defined as the deterioration of TIMI flow grade after mechanical dilatation in the absence of a mechanical obstruction on angiograms. Patients could be divided into the deteriorated flow group (n=21) and the reflow group (n=105). Under these conditions, the presence of thin-cap fibroatheroma (TCFA) was more frequently observed in the deteriorated flow group than in the reflow group in both ACS and SAP. A multivariable logistic regression model revealed that TCFA was an independent predictor of deteriorated coronary flow (hazard ratio: 12.32; 95% confidence interval: 3.02-50.31; p=0.0005). These results demonstrate that TCFA detected by OCT could be a strong predictor of the occurrence of deteriorated coronary flow during stent implantation in ACS as well as SAP. Springer Japan, 2014 No-reflow phenomenon nationallicence Acute coronary syndrome nationallicence Stable angina nationallicence Optical coherence tomography nationallicence Percutaneous coronary intervention nationallicence Gamou Tadatsugu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut Sakata Kenji Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut Matsubara Takao Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut Yasuda Toshihiko Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut Miwa Kenji Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut Inoue Masaru Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut Kanaya Honin Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut Konno Tetsuo Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut Hayashi Kenshi Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut Kawashiri Masaaki Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut Yamagishi Masakazu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut Heart and Vessels Springer Japan 30/6(2015-11-01), 719-727 0910-8327 30:6<719 2015 30 380 https://doi.org/10.1007/s00380-014-0542-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0542-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gamou Tadatsugu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Sakata Kenji Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Matsubara Takao Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut NATIONALLICENCE 700 1- Yasuda Toshihiko Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut NATIONALLICENCE 700 1- Miwa Kenji Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut NATIONALLICENCE 700 1- Inoue Masaru Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut NATIONALLICENCE 700 1- Kanaya Honin Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut NATIONALLICENCE 700 1- Konno Tetsuo Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Hayashi Kenshi Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Kawashiri Masaaki Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 700 1- Yamagishi Masakazu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Ishikawa, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/6(2015-11-01), 719-727 0910-8327 30:6<719 2015 30 380