caa a22 4500 606220828 CHVBK 20210128101125.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00380-014-0553-0 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0553-0 Is pentraxin 3 a biomarker, a player, or both in the context of coronary atherosclerosis and metabolic factors? [Elektronische Daten] [Ayumi Nakamura, Shin-ichiro Miura, Yuhei Shiga, Kenji Norimatsu, Yuiko Miyase, Yasunori Suematsu, Ryoko Mitsutake, Keijiro Saku] The objective of this study is to determine whether pentraxin-3 (PTX-3) is clinically a biomarker of inflammation, a player in anti-inflammation, or both with regard to coronary atherosclerosis, we compared levels of PTX-3 with levels of adiponectin in addition to high-sensitivity C-reactive protein (hs-CRP). We enrolled 693 patients (51% male; mean age 64±12years) at Fukuoka University Hospital. They were clinically suspected to have coronary artery disease (CAD) or had at least one cardiac risk factor and had undergone coronary computed tomography angiography (CTA). We evaluated the levels of PTX-3, hs-CRP, and adiponectin, the presence of CAD or metabolic factors, subcutaneous fat area, visceral fat area (VFA) and lipid profiles. The presence of CAD was independently associated with aging (p=0.010) and the prevalence of hypertension (p<0.0001), but not the levels of PTX-3, hs-CRP and adiponectin by a multivariate analysis. Although the number of significantly stenosed coronary vessels (VD) was not associated with PTX-3 or adiponectin, hs-CRP tended to increase as the number of VD increased. In addition, PTX-3 decreased as the number of metabolic factors increased, whereas hs-CRP increased as the number of metabolic factors increased. Interestingly, PTX-3 did not correlate with hs-CRP, but was positively correlated with adiponectin. In a multiple regression analysis, adiponectin (p=0.003) and VFA (p=0.008) were significant predictors of PTX-3 levels. In conclusion, PTX-3 and adiponectin showed similar associations with metabolic factors, whereas PTX-3 and hs-CRP showed opposite trends. Adiponectin and VFA were significant predictors of PTX-3 levels. PTX-3 might have an atheroprotective role as well as serving as a simple biomarker, like adiponectin. Springer Japan, 2014 Pentraxin-3 nationallicence Inflammation nationallicence Metabolic factors, C-reactive protein nationallicence Adiponectin nationallicence Coronary artery disease nationallicence Coronary computed tomography angiography nationallicence Nakamura Ayumi Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Miura Shin-ichiro Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Shiga Yuhei Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Norimatsu Kenji Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Miyase Yuiko Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Suematsu Yasunori Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Mitsutake Ryoko Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Saku Keijiro Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Heart and Vessels Springer Japan 30/6(2015-11-01), 752-761 0910-8327 30:6<752 2015 30 380 https://doi.org/10.1007/s00380-014-0553-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0553-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakamura Ayumi Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Miura Shin-ichiro Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Shiga Yuhei Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Norimatsu Kenji Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Miyase Yuiko Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Suematsu Yasunori Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Mitsutake Ryoko Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Saku Keijiro Department of Cardiology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/6(2015-11-01), 752-761 0910-8327 30:6<752 2015 30 380