caa a22 4500 606220836 CHVBK 20210128101125.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00380-014-0560-1 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0560-1 Comparison of long-term clinical outcomes between sirolimus- and paclitaxel-eluting stents in real-world clinical practice [Elektronische Daten] [Ryo Naito, Katsumi Miyauchi, Hirokazu Konishi, Shuta Tsuboi, Manabu Ogita, Takatoshi Kasai, Hiroshi Tamura, Shinya Okazaki, Hiroyuki Daida] Advances in percutaneous coronary intervention (PCI) have improved the outcomes of patients with coronary artery diseases. The advent of drug-eluting stents (DES) has dramatically reduced the rate of revascularization. The first-generation DES has yielded the main role of PCI to the second-generation DES; however, many patients had been implanted with the first-generation DES, sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES). Therefore, it is of importance to detect the long-term clinical outcomes in patients who underwent PCI with SES or PES. We analyzed data from our PCI cohort who underwent PCI with first-generation DES at Juntendo University Hospital between August 2004 and June 2010. The index procedure was analyzed when patients underwent multiple PCIs. Patients who were implanted with both SES and PES were excluded from this study. The study ended on December 31, 2011. The primary outcome was a composite of all-cause mortality and acute coronary syndrome (ACS). The secondary outcome was the rate of target lesion revascularization (TLR) and stent thrombosis. We analyzed data from 861 consecutive patients who underwent implantation of SES or PES. The median follow-up period was 1671days (interquartile range 1081 and 2105). Kaplan-Meier curves for the primary endpoint did not significantly differ between the two groups (p=0.8). The incidence of stent thrombosis was 1.4 and 1.8 per 1,000 person-years in the SES and PES groups, respectively (p=0.9). The rate of TLR was significantly lower in the SES, than the PES group (12.6 and 38.3 per 1,000 person-years, p=0.03). The rate of TLR was lower in the group treated with SES than PES, but the primary outcome comprising all-cause mortality and ACS was comparable between the two groups. Springer Japan, 2014 Sirolimus-eluting stent nationallicence Paclitaxel-eluting stent nationallicence Long-term clinical outcomes nationallicence All-cause mortality nationallicence Acute coronary syndrome nationallicence Naito Ryo Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Miyauchi Katsumi Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Konishi Hirokazu Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Tsuboi Shuta Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Ogita Manabu Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Kasai Takatoshi Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Tamura Hiroshi Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Okazaki Shinya Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Daida Hiroyuki Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut Heart and Vessels Springer Japan 30/6(2015-11-01), 746-751 0910-8327 30:6<746 2015 30 380 https://doi.org/10.1007/s00380-014-0560-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0560-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Naito Ryo Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Miyauchi Katsumi Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Konishi Hirokazu Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Tsuboi Shuta Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogita Manabu Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Kasai Takatoshi Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Tamura Hiroshi Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Okazaki Shinya Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Daida Hiroyuki Department of Cardiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/6(2015-11-01), 746-751 0910-8327 30:6<746 2015 30 380