caa a22 4500 606220852 CHVBK 20210128101126.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00380-014-0491-x doi (NATIONALLICENCE)springer-10.1007/s00380-014-0491-x Temporal analysis of regional strain rate during adenosine triphosphate stress before and after percutaneous coronary interventions [Elektronische Daten] [Kazue Gunji, Atsushi Takagi, Kotaro Arai, Kyomi Ashihara, Nobuhisa Hagiwara] Regional myocardial ischemia is thought to be characterized by diastolic dysfunction. We aimed to clarify whether temporal analysis of strain rate (SR) index derived from two-dimensional speckle-tracking echocardiography (2DTE) can assess the regional myocardial ischemia or not. Forty-two patients with significant coronary stenoses were referred for percutaneous coronary intervention (PCI). 2DTE was performed before and a day after PCI. Time from aortic valve closure to peak early diastolic longitudinal SR ∆(TAVC-E SR) was measured both at baseline and during adenosine triphosphate (ATP) infusion. TAVC-E SR was calculated as TAVC-E SR during ATP infusion subtracted by TAVC-E SR at baseline. In forty-five target ischemic regions, TAVC-E SR at baseline was significantly longer than that of control regions (166±28 vs. 136±32ms, P<0.0001). TAVC-E SR in target ischemic regions significantlyprolonged during ATP stress to 221±37ms (P<0.0001), while it did not change in control regions. Immediately after PCI, TAVC-E SR in target regions significantly decreased to 135±27ms, P<0.0001 without prolongation during ATP stress. Receiver operating characteristic curves demonstrated that ∆TAVC-E SR could assess regional myocardial ischemia by a cutoff criterion of 14ms with sensitivity of 93% and specificity of 95%. 2DTE-derived TAVC-E SR significantly increased during ATP stress only in ischemic myocardium. This phenomenon disappeared immediately after PCI. Temporal analysis of TAVC-E SR appeared to be useful to assess the regional myocardial ischemia. Springer Japan, 2014 Coronary artery disease nationallicence Speckle tracking nationallicence Echocardiography nationallicence Adenosine nationallicence Ischemia nationallicence Strain nationallicence Strain rate nationallicence SR : Strain rate nationallicence 2DTE : Two-dimensional speckle-tracking echocardiography nationallicence PCI : Percutaneous coronary intervention nationallicence ATP : Adenosine triphosphate nationallicence LVDd : Left ventricular end-diastolic dimension nationallicence LVDs : Left ventricular end-systolic dimension nationallicence FS : Fractional shortening nationallicence WMSI : Wall motion score index nationallicence e ′ : Tissue Doppler-derived early diastolic velocity of mitral annulus nationallicence PS : Peak systolic strain nationallicence S SR : Peak systolic strain rate nationallicence E SR : Early peak diastolic strain rate nationallicence A SR : Late peak diastolic strain rate nationallicence TAVC- E SR : Time from aortic valve closure to E SR nationallicence ROC : Receiver operating characteristic curves nationallicence Gunji Kazue Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Takagi Atsushi Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Arai Kotaro Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Ashihara Kyomi Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Hagiwara Nobuhisa Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut Heart and Vessels Springer Japan 30/3(2015-05-01), 309-317 0910-8327 30:3<309 2015 30 380 https://doi.org/10.1007/s00380-014-0491-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0491-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gunji Kazue Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Takagi Atsushi Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Arai Kotaro Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Ashihara Kyomi Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 700 1- Hagiwara Nobuhisa Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/3(2015-05-01), 309-317 0910-8327 30:3<309 2015 30 380