caa a22 4500 606220879 CHVBK 20210128101126.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00380-014-0521-8 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0521-8 The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions [Elektronische Daten] [Too Min, Won-Min Jo, Seung Shin, Hong Lim] Heat shock proteins (Hsp) protect myocardial cells from acute stress such as atrial fibrillation (AF) and also from the chronic stress. It is not understood that Hsp70 can prevent AF under cardiomyopathy (CM) conditions. Therefore, we hypothesized that Hsp70 might beneficially influence on the occurrence of AF in CM conditions. We purposed to investigate the correlation between Hsp70 and the AF inducibility in various CM conditions that are unclear. We constructed four different animal models using Sprague-Dawley rats: an ischemic CM group (n=12), a non-ischemic dilated CM group (n=12), a pressure-overload hypertrophic CM group (n=12), and a sham group (CON, n=12). After 4-6weeks of intervention animals, AF was induced acutely prior to hemodynamic studies. Hemodynamic data using the Langendorff technique and histologic evaluation were conducted sequentially in all animal groups. Afterwards, levels of Hsp70 were measured from atrial tissues by real-time polymerase chain reaction study. The hemodynamic data and histologic studies proved that each animal model was suitable to this study protocol. All CM groups showed that Hsp70 was elevated significantly compared to the control groups (P<0.005). Among these CM groups, the TAC group revealed lower Hsp70 levels and higher induction rates of atrial fibrillation than the other groups (P<0.005). The level of Hsp70 was elevated in all the CM models and it was negatively correlated with AF induction rate in sham group. However, we could not find correlation between Hsp70 and AF among the CM models. Springer Japan, 2014 Heat shock protein 70 nationallicence Atrial fibrillation nationallicence Cardiomyopathy nationallicence Min Too Department of Anesthesiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea aut Jo Won-Min Department of Thoracic and Cardiovascular Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Gojan-1-dong, 425-707, Ansan, Gyonggi-do, South Korea aut Shin Seung Division of Cardiology, Heart Research Institute, College of Medicine, Chung-Ang University, Seoul, South Korea aut Lim Hong Division of Cardiology, Cardiovascular Center, Korea University Guro Hospital, Korea University College of Medicine, Ansan, South Korea aut Heart and Vessels Springer Japan 30/3(2015-05-01), 379-385 0910-8327 30:3<379 2015 30 380 https://doi.org/10.1007/s00380-014-0521-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0521-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Min Too Department of Anesthesiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea aut NATIONALLICENCE 700 1- Jo Won-Min Department of Thoracic and Cardiovascular Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Gojan-1-dong, 425-707, Ansan, Gyonggi-do, South Korea aut NATIONALLICENCE 700 1- Shin Seung Division of Cardiology, Heart Research Institute, College of Medicine, Chung-Ang University, Seoul, South Korea aut NATIONALLICENCE 700 1- Lim Hong Division of Cardiology, Cardiovascular Center, Korea University Guro Hospital, Korea University College of Medicine, Ansan, South Korea aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/3(2015-05-01), 379-385 0910-8327 30:3<379 2015 30 380