caa a22 4500 606220909 CHVBK 20210128101126.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00380-014-0480-0 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0480-0 Effects of the PPARγ agonist pioglitazone on coronary atherosclerotic plaque composition and plaque progression in non-diabetic patients: a double-center, randomized controlled VH-IVUS pilot-trial [Elektronische Daten] [Marian Christoph, Joerg Herold, Anna Berg-Holldack, Thomas Rauwolf, Tjalf Ziemssen, Alexander Schmeisser, Sönke Weinert, Bernd Ebner, Samir Said, Ruth Strasser, Ruediger Braun-Dullaeus] Despite the advanced therapy with statins, antithrombotics and antihypertensive agents, the medical treatment of coronary artery disease is less than optimal. Therefore, additional therapeutic anti-atherosclerotic options are desirable. This VH-IVUS study (intravascular ultrasonography with virtual histology) was performed to assess the potential anti-atherogenic effect of the PPARγ agonist pioglitazone in non-diabetic patients. A total of 86 non-culprit atherosclerotic lesions in 54 patients with acute coronary syndrome were observed in a 9-month prospective, double-blind, and placebo-controlled IVUS study. Patients were randomized to receive either 30mg pioglitazone (Pio) or placebo (Plac). As primary efficacy parameter, the change of relative plaque content of necrotic core was determined by serial VH-IVUS analyses. Main secondary endpoint was the change of total plaque volume. In contrast to placebo, in the pioglitazone-treated group, the relative plaque content of necrotic core decreased significantly (Pio −1.3±6.9% vs. Plac +2.6±6.5%, p<0.01). In comparison to the placebo group, the plaques in pioglitazone-treated patients showed significantly greater reduction of the total plaque volume (Pio −16.1±26.4mm3 vs. Plac −1.8±30.9mm3, p=0.02). Treatment with a PPARγ agonist in non-diabetic patients results in a coronary artery plaque stabilization on top of usual medical care. Springer Japan, 2014 Cardiovascular disease nationallicence Thiazolidinediones nationallicence Intravascular ultrasonography nationallicence Atherosclerotic plaque progression, atherosclerotic plaque composition nationallicence Christoph Marian Heart Center, University of Dresden, University Hospital, Germany, Fetscherstrasse 76, 01307, Dresden, Germany aut Herold Joerg Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut Berg-Holldack Anna Heart Center, University of Dresden, University Hospital, Germany, Fetscherstrasse 76, 01307, Dresden, Germany aut Rauwolf Thomas Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut Ziemssen Tjalf Department of Neurology, University Hospital, Germany, Dresden, Germany aut Schmeisser Alexander Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut Weinert Sönke Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut Ebner Bernd Heart Center, University of Dresden, University Hospital, Germany, Fetscherstrasse 76, 01307, Dresden, Germany aut Said Samir Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut Strasser Ruth Heart Center, University of Dresden, University Hospital, Germany, Fetscherstrasse 76, 01307, Dresden, Germany aut Braun-Dullaeus Ruediger Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut Heart and Vessels Springer Japan 30/3(2015-05-01), 286-295 0910-8327 30:3<286 2015 30 380 https://doi.org/10.1007/s00380-014-0480-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0480-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Christoph Marian Heart Center, University of Dresden, University Hospital, Germany, Fetscherstrasse 76, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Herold Joerg Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Berg-Holldack Anna Heart Center, University of Dresden, University Hospital, Germany, Fetscherstrasse 76, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Rauwolf Thomas Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Ziemssen Tjalf Department of Neurology, University Hospital, Germany, Dresden, Germany aut NATIONALLICENCE 700 1- Schmeisser Alexander Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Weinert Sönke Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Ebner Bernd Heart Center, University of Dresden, University Hospital, Germany, Fetscherstrasse 76, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Said Samir Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Strasser Ruth Heart Center, University of Dresden, University Hospital, Germany, Fetscherstrasse 76, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Braun-Dullaeus Ruediger Internal Medicine, Division of Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Germany aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/3(2015-05-01), 286-295 0910-8327 30:3<286 2015 30 380