caa a22 4500 60622100X CHVBK 20210128101126.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00380-014-0496-5 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0496-5 Prediction of left atrial thrombi in patients with atrial tachyarrhythmias during warfarin administration: retrospective study in Hyogo College of Medicine [Elektronische Daten] [Hideyuki Kishima, Takanao Mine, Takeshi Kodani, Tohru Masuyama] Some patients experience a left atrial thrombus (LAT) in spite of taking warfarin. We aimed to clarify the characteristics of patients with LAT during warfarin administration and investigated whether the CHADS2 or CHA2DS2-VASc scores are useful predictors of LAT. We studied 230 patients (169 males, age 65±10years) who underwent transesophageal echocardiography (TEE) prior to cardioversion or catheter ablation of atrial tachyarrhythmias between 2008 and 2012. All patients were taking oral warfarin. LAT was detected in 19 patients (8.3%) using TEE. LAT was significantly associated with the presence of hypertension (P=0.0035), prior congestive heart failure (P<0.0001), structural heart disease (P=0.0012), persistent arrhythmias (P<0.0001), the absence of SR during TEE (P=0.0070), left ventricular ejection fraction (P<0.0001), left atrial diameter (P=0.0015), left ventricular dimension during end diastole (P=0.0215), left ventricular hypertrophy (LVH; P<0.0001), and the E/e′ ratio (P=0.0074). A multivariate analysis showed that LVH (P=0.0065, OR 5.591, 95% CI 1.618-19.316) and persistent arrhythmia (P=0.0364, OR 12.121, 95% CI 1.171-125.451) were independently associated with LAT. Moreover, the mean CHADS2 (2.3±0.9 vs. 1.4±1.2) and CHA2DS2-VASc scores (3.8±1.2 vs. 2.8±1.7) were higher in the patients with than without LAT. However, a multivariate analysis showed that the CHADS2/CHA2DS2-VASc scores did not associate with LAT. LVH and persistent arrhythmia may be useful for predicting LAT in patients with atrial tachyarrhythmias. Springer Japan, 2014 Transesophageal echocardiography nationallicence Left atrial thrombus nationallicence Atrial tachyarrhythmia nationallicence Warfarin nationallicence Kishima Hideyuki Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan aut Mine Takanao Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan aut Kodani Takeshi Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan aut Masuyama Tohru Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan aut Heart and Vessels Springer Japan 30/3(2015-05-01), 331-337 0910-8327 30:3<331 2015 30 380 https://doi.org/10.1007/s00380-014-0496-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0496-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kishima Hideyuki Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Mine Takanao Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Kodani Takeshi Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Masuyama Tohru Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/3(2015-05-01), 331-337 0910-8327 30:3<331 2015 30 380