caa a22 4500 606221026 CHVBK 20210128101126.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00380-014-0487-6 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0487-6 ECMO for pulmonary rescue in an adult with amiodarone-induced toxicity [Elektronische Daten] [Filippo Benassi, Alberto Molardi, Elena Righi, Rosaria Santangelo, Marco Meli] Amiodarone is a highly effective antiarrhythmic agent. Unfortunately amiodarone-induced pulmonary toxicity is described for medium-long term therapy. We describe a case of a 65-year-old man admitted to our department for breathlessness and with a history of recurrent episodes of atrial fibrillation for which he had been receiving amiodarone (200mg/day) since 2008. Despite diuretic therapy, along with aspirin, statins and antibiotics the patient continued to complain of severe dyspnea and had a moderate fever. Thus, diagnostic hypotheses different from acute cardiac failure were considered, in particular non-cardiogenic causes of pulmonary infiltrates. Following suspicion of amiodarone-induced pulmonary toxicity, the drug was discontinued and corticosteroid therapy was initiated. Due to the deterioration of the clinical picture, we proceeded to intubation. After few hours from intubation we were forced to institute a veno-venous extracorporeal membrane oxygenation due to the worsening of pulmonary function. The patient's clinical condition improved which allowed us to remove the ECMO after 15days of treatment. Indications for use of ECMO have expanded considerably. To our knowledge this is the first successful, reported article of a veno-venous ECMO used to treat amiodarone-induced toxicity in an adult. In patients with severe but potentially reversible pulmonary toxicity caused by amiodarone, extracorporeal life support can maintain pulmonary function and vital organ perfusion at the expense of low morbidity, while allowing time for drug clearance. Springer Japan, 2014 Cardiopulmonary bypass nationallicence Circulatory support devices nationallicence Extracorporeal membrane oxygenation nationallicence ECMO nationallicence Atrial fibrillation (AF) nationallicence Flutter nationallicence Interstitial lung disease nationallicence Benassi Filippo Dipartimento Cardio-Nefro-Polmonare, Unità complessa di Cardiochirurgia, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci No 14, 43126, Parma, Italy aut Molardi Alberto Dipartimento Cardio-Nefro-Polmonare, Unità complessa di Cardiochirurgia, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci No 14, 43126, Parma, Italy aut Righi Elena Dipartimento di Cardiologia Medico-Chirurgica Toraco-Vascolare, Hesperia Hospital, Via Arquà 80/a, Modena, Italy aut Santangelo Rosaria Dipartimento di Cardiologia Medico-Chirurgica Toraco-Vascolare, Hesperia Hospital, Via Arquà 80/a, Modena, Italy aut Meli Marco Dipartimento di Cardiologia Medico-Chirurgica Toraco-Vascolare, Hesperia Hospital, Via Arquà 80/a, Modena, Italy aut Heart and Vessels Springer Japan 30/3(2015-05-01), 410-415 0910-8327 30:3<410 2015 30 380 https://doi.org/10.1007/s00380-014-0487-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0487-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Benassi Filippo Dipartimento Cardio-Nefro-Polmonare, Unità complessa di Cardiochirurgia, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci No 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Molardi Alberto Dipartimento Cardio-Nefro-Polmonare, Unità complessa di Cardiochirurgia, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci No 14, 43126, Parma, Italy aut NATIONALLICENCE 700 1- Righi Elena Dipartimento di Cardiologia Medico-Chirurgica Toraco-Vascolare, Hesperia Hospital, Via Arquà 80/a, Modena, Italy aut NATIONALLICENCE 700 1- Santangelo Rosaria Dipartimento di Cardiologia Medico-Chirurgica Toraco-Vascolare, Hesperia Hospital, Via Arquà 80/a, Modena, Italy aut NATIONALLICENCE 700 1- Meli Marco Dipartimento di Cardiologia Medico-Chirurgica Toraco-Vascolare, Hesperia Hospital, Via Arquà 80/a, Modena, Italy aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/3(2015-05-01), 410-415 0910-8327 30:3<410 2015 30 380