caa a22 4500 606221034 CHVBK 20210128101126.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00380-014-0485-8 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0485-8 Prognostic impact of regional arterial stiffness in hypertensive patients [Elektronische Daten] [Tatsuo Kawai, Mitsuru Ohishi, Miyuki Onishi, Norihisa Ito, Yasushi Takeya, Ryosuke Oguro, Yoichi Takami, Koichi Yamamoto, Hiromi Rakugi] Many reports have shown that brachial-ankle pulse wave velocity (baPWV) and carotid-femoral PWV are prognostic factors for cardiovascular diseases. We evaluated heart-carotid PWV, heart-femoral PWV (hfPWV), and femoral-ankle PWV (faPWV) using carotid and femoral sensors. Our objectives were to reveal correlations among PWVs and to determine the clinical importance of the respective PWVs in predicting the cardiovascular events. This prospective cohort study included 338 patients with essential hypertension (mean age 61.3±0.7, mean follow-up period 6.5±0.1years) whose regional PWVs were measured. Primary end points were stroke, cardiovascular diseases (CVD), and death. Kaplan-Meier analysis showed that subjects with higher faPWV and baPWV had a significantly higher incidence of stroke (p=0.0288 and 0.0277, respectively), subjects with higher hfPWV had a significantly higher incidence of CVD (p=0.0212), subjects with higher baPWV and hfPWV had a significantly higher incidence of stroke+CVD (p=0.0070 and 0.0463, respectively), and subjects with higher baPWV had a significantly higher mortality rate (p=0.0367). Cox proportional hazard model revealed that baPWV was a significant risk factor for stroke+CVD after adjustment for traditional risk factors (relative risk: 14.50, p=0.0288). Higher baPWV may be a risk factor for stroke and CVD, but the prognostic impact of regional PWVs is still unclear in patients with hypertension. Springer Japan, 2014 Cardiovascular disease nationallicence Prognosis nationallicence Regional pulse wave velocity nationallicence Kawai Tatsuo Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Ohishi Mitsuru Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Onishi Miyuki Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Ito Norihisa Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Takeya Yasushi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Oguro Ryosuke Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Takami Yoichi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Yamamoto Koichi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Rakugi Hiromi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut Heart and Vessels Springer Japan 30/3(2015-05-01), 338-346 0910-8327 30:3<338 2015 30 380 https://doi.org/10.1007/s00380-014-0485-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0485-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawai Tatsuo Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Ohishi Mitsuru Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Onishi Miyuki Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Ito Norihisa Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Takeya Yasushi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Oguro Ryosuke Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Takami Yoichi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yamamoto Koichi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Rakugi Hiromi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka (B6), 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/3(2015-05-01), 338-346 0910-8327 30:3<338 2015 30 380