caa a22 4500 606221077 CHVBK 20210128101127.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00380-014-0495-6 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0495-6 Acute changes of left ventricular hemodynamics and function during percutaneous coronary intervention in patients with unprotected left main coronary artery disease [Elektronische Daten] [Seong-Mi Park, Chul-Min Ahn, Soon-Jun Hong, Yong-Hyun Kim, Jae-Hyoung Park, Wan-Joo Shim, Do-Sun Lim] Percutaneous coronary interventions (PCIs) are increasingly being used to treat unprotected left main coronary artery (ULMCA) lesions. However, research is sparse on the acute changes of left ventricular (LV) hemodynamics and function during PCI in patients with ULMCA stenosis. We aimed to assess the acute changes of LV function using speckle-tracking imaging during PCI in these patients. Fifteen consecutive patients who underwent elective PCI for ULMCA stenosis were enrolled. Echocardiographic studies and pressure measurement were performed at baseline, during PCI and after PCI. LMCA occlusion with a first balloon inflation induced a marked reduction in the peak positive derivative of LV pressure (dP/dt max), LV global longitudinal strain (GLS), and systolic and diastolic strain rates, and a marked increase in LV end-diastolic pressure (EDP) (all P<0.01). During the second inflation, the degrees of LV hemodynamic and functional changes were similar to those of the first inflation, even with a higher inflation pressure. During the third inflation, the values of GLS and dP/dt max were higher than those of the second inflation (P=0.03 and P=0.05, respectively). After optimal PCI, dP/dt max, LVEDP, and strain parameters were improved to baseline values. LV hemodynamics and function were considerably impaired with the first ballooning during PCI for ULMCA stenosis. However, the degrees of LV hemodynamic and functional changes decreased with each successive balloon inflation, which can be explained by ischemic preconditioning. After all procedures were safely completed, LV systolic function was improved without LV diastolic stunning. Springer Japan, 2014 Left main disease nationallicence Percutaneous coronary intervention nationallicence Left ventricle nationallicence Strain nationallicence Park Seong-Mi Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut Ahn Chul-Min Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut Hong Soon-Jun Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut Kim Yong-Hyun Division of Cardiology, Ansan Hospital, Korea University College of Medicine, 123 Jeokgeum-ro, Danwon-gu, Ansan, Republic of Korea aut Park Jae-Hyoung Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut Shim Wan-Joo Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut Lim Do-Sun Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut Heart and Vessels Springer Japan 30/4(2015-07-01), 432-440 0910-8327 30:4<432 2015 30 380 https://doi.org/10.1007/s00380-014-0495-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0495-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Seong-Mi Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Ahn Chul-Min Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Hong Soon-Jun Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim Yong-Hyun Division of Cardiology, Ansan Hospital, Korea University College of Medicine, 123 Jeokgeum-ro, Danwon-gu, Ansan, Republic of Korea aut NATIONALLICENCE 700 1- Park Jae-Hyoung Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Shim Wan-Joo Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Lim Do-Sun Division of Cardiology, Anam Hospital, Korea University College of Medicine, 126-1 Anamdong-5-ga, Seongbuk-gu, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/4(2015-07-01), 432-440 0910-8327 30:4<432 2015 30 380