caa a22 4500 60622114X CHVBK 20210128101127.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00380-014-0512-9 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0512-9 Impact of secondary hyperparathyroidism on ventricular mass regression after aortic valve replacement for aortic stenosis in hemodialysis-dependent patients [Elektronische Daten] [Yoshiyuki Takami, Kazuyoshi Tajima] In hemodialysis (HD)-dependent patients, secondary hyperparathyroidism induces cardiac hypertrophy. This study investigated whether parathyroid hormone (PTH) levels affect the degree of left ventricular (LV) mass regression in HD patients after aortic valve replacement (AVR) for aortic stenosis (AS). We retrospectively obtained preoperative and 2-year postoperative echocardiography and intact PTH measurements in 88 HD patients who underwent AVR, with bioprostheses (n=35, 40%) and mechanical valves (n=53, 60%) of effective orifice area >0.80cm2/m2, between January 1997 and December 2010. The LV mass decreased significantly from 308±88 to 217±68g at follow-up of 28±4months after AVR (p<0.001). The LV mass regression at follow-up was inversely related to preoperative PTH values (R=0.44, p=0.001). The LV mass regression at follow-up was significantly smaller in the patients (n=47) with PTH ≥100pg/mL than in those (n=41) with PTH <100pg/mL throughout the study period (61±75 versus 108±49g, p<0.0001). After adjusting for female sex, hypertension, and baseline LV mass, high PTH values were found to be independent predictor of less LV mass regression at 2-year follow-up (β=0.23, r 2 =0.24, p=0.02). In conclusion, the HD patients with high levels of PTH presented with less LV mass regression after AVR for AS without patient-prosthesis mismatch. Secondary hyperparathyroidism may impair regression of cardiac hypertrophy after AVR in HD patients with AS. Springer Japan, 2014 Aortic valve replacement nationallicence Left ventricular hypertrophy nationallicence Hemodialysis nationallicence Secondary hyperparathyroidism nationallicence Takami Yoshiyuki Department of Cardiovascular Surgery, Kansai Medical University, Takii Hospital, 10-15 Fumizono-cho, 570-8507, Moriguchi, Japan aut Tajima Kazuyoshi Department of Cardiovascular Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan aut Heart and Vessels Springer Japan 30/4(2015-07-01), 510-515 0910-8327 30:4<510 2015 30 380 https://doi.org/10.1007/s00380-014-0512-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0512-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takami Yoshiyuki Department of Cardiovascular Surgery, Kansai Medical University, Takii Hospital, 10-15 Fumizono-cho, 570-8507, Moriguchi, Japan aut NATIONALLICENCE 700 1- Tajima Kazuyoshi Department of Cardiovascular Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/4(2015-07-01), 510-515 0910-8327 30:4<510 2015 30 380