caa a22 4500 606221158 CHVBK 20210128101127.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00380-014-0505-8 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0505-8 Impact of duration and dosage of statin treatment and epicardial fat thickness on the recurrence of atrial fibrillation after electrical cardioversion [Elektronische Daten] [Kyoung-Im Cho, Bong-Joon Kim, Tae-Joon Cha, Jung-Ho Heo, Hyun-Su Kim, Jae-Woo Lee] The purpose of this study was to investigate the time-dependent effect of statin treatment and echocardiographic epicardial fat thickness (EFT) on the maintenance of sinus rhythm (SR) in atrial fibrillation (AF) patients after electrical cardioversion (EC). One hundred sixty-three AF patients without previous statin treatment who underwent EC were consecutively enrolled. The maintenance rate of SR after EC (1, 3, 6, and 12months) as documented by electrocardiogram and EFT were compared between patients with statin treatment (statin group, n=63) and those without (no statin group, n=100). There was no significant difference in the maintenance rate of SR between the groups soon after EC (statin group; 85.7% vs. no statin; 84.8%, p=0.535), after 1month (71.0 vs. 59.1%, p=0.091), and after 3months (63.2 vs. 50.0%, p=0.086). However, the maintenance rate of SR was significantly higher in the statin group compared to no statin group (61.8 vs. 42.9%, p=0.024) after 6months, and this significant difference persisted up to 12months of follow up (60.1 vs. 36.4%, p=0.001). Patients with recurrence showed higher baseline EFT (7.4±2.7 vs. 8.5±3.0mm, p=0.014). Multivariate linear regression analysis indicated that EFT, left atrial diameter, high-density lipoprotein cholesterol, statin treatment, and dose were the significant contributors to the maintenance of SR for all periods after EC. Statin treatment and low EFT were associated with a higher maintenance rate of SR in AF patients after EC. Significant benefit of statin was realized 6months after EC, and this benefit was shown to be maintained over time. Springer Japan, 2014 Statin nationallicence Atrial fibrillation nationallicence Electrical cardioversion nationallicence Epicardial fat thickness nationallicence Cho Kyoung-Im Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut Kim Bong-Joon Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut Cha Tae-Joon Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut Heo Jung-Ho Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut Kim Hyun-Su Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut Lee Jae-Woo Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut Heart and Vessels Springer Japan 30/4(2015-07-01), 490-497 0910-8327 30:4<490 2015 30 380 https://doi.org/10.1007/s00380-014-0505-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0505-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cho Kyoung-Im Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut NATIONALLICENCE 700 1- Kim Bong-Joon Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut NATIONALLICENCE 700 1- Cha Tae-Joon Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut NATIONALLICENCE 700 1- Heo Jung-Ho Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut NATIONALLICENCE 700 1- Kim Hyun-Su Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut NATIONALLICENCE 700 1- Lee Jae-Woo Division of Cardiology, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/4(2015-07-01), 490-497 0910-8327 30:4<490 2015 30 380