caa a22 4500 606221174 CHVBK 20210128101127.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00380-014-0525-4 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0525-4 A novel technique to predict pulmonary capillary wedge pressure utilizing central venous pressure and tissue Doppler tricuspid/mitral annular velocities [Elektronische Daten] [Kazunori Uemura, Masashi Inagaki, Can Zheng, Meihua Li, Toru Kawada, Masaru Sugimachi] Assessing left ventricular (LV) filling pressure (pulmonary capillary wedge pressure, PCWP) is an important aspect in the care of patients with heart failure (HF). Physicians rely on right ventricular (RV) filling pressures such as central venous pressure (CVP) to predict PCWP, assuming concordance between CVP and PCWP. However, the use of this method is limited because discordance between CVP and PCWP is observed. We hypothesized that PCWP can be reliably predicted by CVP corrected by the relationship between RV and LV function, provided by the ratio of tissue Doppler peak systolic velocity of tricuspid annulus (S T) to that of mitral annulus (S M) (corrected CVP:CVP·S T/S M). In 16 anesthetized closed-chest dogs, S T and S M were measured by transthoracic tissue Doppler echocardiography. PCWP was varied over a wide range (1.8-40.0mmHg) under normal condition and various types of acute and chronic HF. A significantly stronger linear correlation was observed between CVP·S T/S M and PCWP (R 2=0.78) than between CVP and PCWP (R 2=0.22) (P<0.01). Receiver-operating characteristic (ROC) analysis indicated that CVP·S T/S M >10.5mmHg predicted PCWP >18mmHg with 85% sensitivity and 88% specificity. Area under ROC curve for CVP·S T/S M to predict PCWP >18mmHg was 0.93, which was significantly larger than that for CVP (0.66) (P<0.01). Peripheral venous pressure (PVP) corrected by S T/S M (PVP·S T/S M) also predicted PCWP reasonably well, suggesting that PVP·S T/S M may be a minimally invasive alternative to CVP·S T/S M. In conclusion, our technique is potentially useful for the reliable prediction of PCWP in HF patients. Springer Japan, 2014 Heart failure nationallicence Hemodynamics nationallicence Echocardiography nationallicence Uemura Kazunori Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut Inagaki Masashi Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut Zheng Can Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut Li Meihua Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut Kawada Toru Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut Sugimachi Masaru Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut Heart and Vessels Springer Japan 30/4(2015-07-01), 516-526 0910-8327 30:4<516 2015 30 380 https://doi.org/10.1007/s00380-014-0525-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0525-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uemura Kazunori Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Inagaki Masashi Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Zheng Can Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Li Meihua Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Kawada Toru Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Sugimachi Masaru Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, 565-8565, Suita, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/4(2015-07-01), 516-526 0910-8327 30:4<516 2015 30 380