caa a22 4500 606221212 CHVBK 20210128101127.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00380-014-0502-y doi (NATIONALLICENCE)springer-10.1007/s00380-014-0502-y Lower 1,5-anhydroglucitol is associated with denovo coronary artery disease in patients at high cardiovascular risk [Elektronische Daten] [Takayuki Fujiwara, Masashi Yoshida, Hodaka Yamada, Takunori Tsukui, Tomohiro Nakamura, Kenichi Sakakura, Hiroshi Wada, Kenshiro Arao, Takuji Katayama, Hiroshi Funayama, Yoshitaka Sugawara, Takeshi Mitsuhashi, Masafumi Kakei, Shin-ichi Momomura, Junya Ako] Postprandial hyperglycemia is a risk factor for cardiovascular disease and mortality. Serum 1,5-anhydroglucitol (1,5-AG) level is an useful clinical marker of glucose metabolism which reflects postprandial hyperglycemia more robustly compared to hemoglobin A1c (HbA1c). Relationship between serum 1,5-AG level and cardiovascular disease has been reported; however, comparison between HbA1c and 1,5-AG as markers of cardiovascular disease was not performed. We included 227 consecutive patients who underwent coronary angiography meeting the following inclusion criteria: (1) patients who had no history of coronary artery disease (CAD); (2) patients without acute coronary syndrome; (3) patients without poorly controlled diabetes mellitus; (4) patients without anemia, liver dysfunction, acute, and chronic renal failure and malnutrition; and (5) patients without adhibition of acarbose or Chinese herbal medicine. We measured HbA1c, glycoalbumin, and 1,5-AG. Serum 1,5-AG was significantly lower in patients with CAD (16.6±8.50 vs. 21.1±7.97μg/ml, P<0.001). Multivariable logistic regression analysis showed decrease in serum 1,5-AG was independently associated with the presence of denovo CAD (0.93, 95% CI 0.88-0.98, P=0.006). Serum 1,5-AG was also independently associated with the presence of denovo CAD in patients without diabetes mellitus (0.94, 95% CI 0.88-0.99, P=0.046). In conclusion, lower serum 1,5-AG was associated with the presence of denovo CAD. Serum 1,5-AG may identify high cardiovascular risk patients for denovo CAD in both diabetic and non-diabetic patients. Springer Japan, 2014 1,5-Anhydroglucitol nationallicence Coronary artery disease nationallicence Postprandial hyperglycemia nationallicence Diabetes mellitus nationallicence Fujiwara Takayuki Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Yoshida Masashi Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan aut Yamada Hodaka Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan aut Tsukui Takunori Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Nakamura Tomohiro Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Sakakura Kenichi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Wada Hiroshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Arao Kenshiro Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Katayama Takuji Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Funayama Hiroshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Sugawara Yoshitaka Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Mitsuhashi Takeshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Kakei Masafumi Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan aut Momomura Shin-ichi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Ako Junya Department of Cardiovascular Medicine, Kitasato University, Tokyo, Japan aut Heart and Vessels Springer Japan 30/4(2015-07-01), 469-476 0910-8327 30:4<469 2015 30 380 https://doi.org/10.1007/s00380-014-0502-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0502-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujiwara Takayuki Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Yoshida Masashi Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan aut NATIONALLICENCE 700 1- Yamada Hodaka Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan aut NATIONALLICENCE 700 1- Tsukui Takunori Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Nakamura Tomohiro Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Sakakura Kenichi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Wada Hiroshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Arao Kenshiro Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Katayama Takuji Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Funayama Hiroshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Sugawara Yoshitaka Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Mitsuhashi Takeshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Kakei Masafumi Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan aut NATIONALLICENCE 700 1- Momomura Shin-ichi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Ako Junya Department of Cardiovascular Medicine, Kitasato University, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/4(2015-07-01), 469-476 0910-8327 30:4<469 2015 30 380