caa a22 4500 606221220 CHVBK 20210128101127.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00380-014-0501-z doi (NATIONALLICENCE)springer-10.1007/s00380-014-0501-z Late aneurysm formation of Valsalva sinus after aortic valve replacement due to Takayasu's arteritis [Elektronische Daten] [Akira Funada, Hideaki Kanzaki, Nobutaka Nagano, Yasuo Sugano, Takahiro Ohara, Takuya Hasegawa, Hatsue Ishibashi-Ueda, Masafumi Kitakaze, Toshihisa Anzai] Takayasu's arteritis (TA) is an inflammatory disease of unknown etiology involving the aorta and its branches, and also causes aortic regurgitation (AR). One of the most serious but rare complications after aortic valve replacement (AVR) in TA is aneurysm formation of the sinus of Valsalva. A 64-year-old woman had undergone AVR with a prosthetic valve for AR due to TA 4years earlier and had received an implanted permanent pacemaker for complete atrioventricular block (AVB) 2years later. Aortography 4years postoperatively demonstrated aneurysm formation (47mm in diameter) at the sinus of Valsalva although preoperative aortography showed severe AR without dilatation of the sinus of Valsalva. We recommended reoperation for the aneurysm but the patient refused. The perioperative histopathological examination revealed extensive destruction of the medial elastic fibers. Both the fragility of the sinus of Valsalva and the residual inflammation could have caused the patient's aneurysm formation. Moreover, extension of TA into the ventricular septum or mechanical compression of the aneurysm against the conduction system might have caused her progressive AVB. Close and lifelong follow-up for patients with TA regarding development of aneurysm after surgical treatment is indispensable when fragility of the aortic root had been confirmed. Springer Japan, 2014 Takayasu's arteritis nationallicence Aneurysm nationallicence Valsalva sinus nationallicence Atrioventricular block nationallicence Funada Akira Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut Kanzaki Hideaki Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut Nagano Nobutaka Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut Sugano Yasuo Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut Ohara Takahiro Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut Hasegawa Takuya Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut Ishibashi-Ueda Hatsue Department of Pathology, National Cerebral and Cardiovascular Center, Suita, Japan aut Kitakaze Masafumi Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut Anzai Toshihisa Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut Heart and Vessels Springer Japan 30/4(2015-07-01), 558-562 0910-8327 30:4<558 2015 30 380 https://doi.org/10.1007/s00380-014-0501-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0501-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Funada Akira Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Kanzaki Hideaki Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Nagano Nobutaka Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Sugano Yasuo Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Ohara Takahiro Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Hasegawa Takuya Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Ishibashi-Ueda Hatsue Department of Pathology, National Cerebral and Cardiovascular Center, Suita, Japan aut NATIONALLICENCE 700 1- Kitakaze Masafumi Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut NATIONALLICENCE 700 1- Anzai Toshihisa Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, 565-8565, Suita, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/4(2015-07-01), 558-562 0910-8327 30:4<558 2015 30 380