caa a22 4500 606221247 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0526-3 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0526-3 Effect of purified eicosapentaenoic acid on red cell distribution width in patients with ischemic heart disease [Elektronische Daten] [Masao Takahashi, Masahiro Myojo, Aya Watanabe, Arihiro Kiyosue, Koichi Kimura, Jiro Ando, Yasunobu Hirata, Issei Komuro] A recent study showed eicosapentaenoic acid (EPA) is a promising treatment for prevention of coronary events in hypercholesterolemic patients. Meanwhile, a high red blood cell distribution width (RDW) is a known risk factor for cardiovascular events. However, few studies have addressed the association between EPA levels and RDW. We examined whether EPA administration reduced the levels of RDW in patients with ischemic heart disease (IHD). We retrospectively analyzed the data of 66 EPA-treated IHD patients, and these EPA-treated patients were compared with control IHD patients. The median follow-up period was 189days in EPA-treated patients. All patients were not associated with anemia. In the follow-up period, the ratio of EPA levels to arachidonic acid levels (EPA/AA) was significantly increased. A significant decrease was observed in RDW at follow-up [ΔRDW (%); EPA vs. control=−0.34±0.84 (SD) vs. 0.08±0.86, P<0.01]. These RDW changes were more marked in diabetic patients with high serum levels of high-sensitive C-reactive protein (hs-CRP) [ΔRDW (%); EPA vs. control=−0.53±0.69 vs. 0.56±0.85, P<0.01]. There was no correlation between the amount of change in EPA/AA and RDW (R=0.037, P=0.32), but a significant negative correlation was observed in diabetic patients with high hs-CRP levels (N=14, R=−0.506, P=0.046). In conclusion, EPA has the potential to reduce RDW in IHD patients. This effect was intensified especially among diabetic patients with high hs-CRP levels. IHD patients with high RDW levels may be suitable for treatment with purified EPA. Springer Japan, 2014 Eicosapentaenoic acid (EPA) nationallicence Red blood cell distribution width (RDW) nationallicence Diabetes mellitus nationallicence High-sensitive C-reactive protein (hs-CRP) nationallicence Ischemic heart disease (IHD) nationallicence EPA : Eicosapentaenoic acid nationallicence AA : Arachidonic acid nationallicence DHA : Docosahexaenoic acid nationallicence PUFAs : n-3 Polyunsaturated fatty acids nationallicence RDW : Red blood cell distribution width nationallicence IHD : Ischemic heart disease nationallicence hs-CRP : High-sensitive C-reactive protein nationallicence RBC : Red blood cell nationallicence PCI : Percutaneous coronary intervention nationallicence CABG : Coronary artery bypass grafting nationallicence OMI : Old myocardial infarction nationallicence DM : Diabetes mellitus nationallicence HbA1c : Hemoglobin A1c nationallicence TGL : Triglycerides nationallicence Cr : Serum creatinine nationallicence eGFR : Estimated glomerular filtration rate nationallicence EPA/AA : Ratio of EPA to AA nationallicence ACS : Acute coronary syndrome nationallicence Takahashi Masao Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut Myojo Masahiro Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut Watanabe Aya Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut Kiyosue Arihiro Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut Kimura Koichi Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut Ando Jiro Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut Hirata Yasunobu Department of Cardiovascular Medicine, Tokyo Teishin Hospital, Tokyo, Japan aut Komuro Issei Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut Heart and Vessels Springer Japan 30/5(2015-09-01), 587-594 0910-8327 30:5<587 2015 30 380 https://doi.org/10.1007/s00380-014-0526-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0526-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takahashi Masao Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Myojo Masahiro Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Watanabe Aya Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Kiyosue Arihiro Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Kimura Koichi Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Ando Jiro Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirata Yasunobu Department of Cardiovascular Medicine, Tokyo Teishin Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Komuro Issei Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 587-594 0910-8327 30:5<587 2015 30 380